Vol. 25 (1-2) 2004 Neuro endocrinology letters

Impaired somatostatin accumulation within the median eminence in mice with mosaic mutation.

OBJECTIVES: The mosaic mutation (Atp7a(mo-ms)) linked to X-chromosome is caused by changes in the Atp7a gene encoding CPx-type protein responsible for the ATP-dependent copper transport across cell membranes. Mosaic mutant males represent an animal model for Menkes disease in humans. Starting from the eighth day of life the mosaic males.....