Vol. 25 (6) 2004 Neuro endocrinology letters

The presence of heme-oxygenase and biliverdin reductase in human cranial ganglia indicates a role for carbon monoxide in neural transmission.

OBJECTIVES: The purpose of this study was to localize in cranial ganglia of man the occurrence of the putative gaseous neural messenger carbon monoxide (CO) and the biliverdin degrading enzyme biliverdin reductase (BVR).

METHODS: Immunocytochemistry with antibodies against the CO-inducing enzymes HO-1, HO-2, BVR .....