A new mutation in WFS1 gene (C.1522-1523delTA, Y508fsX421) may be responsible for early appearance of clinical features of Wolfram syndrome and suicidal behaviour.

Aluclu M, Bahceci M, Tuzcu A, Arikan S, Gokalp D.

Case Reports 2006; 27(6): 691-694 PubMed PMID: 17187023 Keywords: Age of Onset, Gene Deletion, Humans, Male, Membrane Proteins:genetics, Mental Disorders:complications, Pedigree, Severity of Illness Index, Suicide, Urologic Diseases:complications, Wolfram Syndrome:complications,.

OBJECTIVE: Wolfram syndrome (WS) is an autosomal recessive disorder characterized by the association of juvenile-onset diabetes mellitus and optic atrophy. It is also known by the acronym DIDMOAD (diabetes insipidus, diabetes mellitus, optic atrophy, and deafness).

PATIENTS, METHODS AND RESULTS: We diagnosed Wolf.....

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Vol. 27 (6) 2006 Neuro endocrinology letters

A new mutation in WFS1 gene (C.1522-1523delTA, Y508fsX421) may be responsible for early appearance of clinical features of Wolfram syndrome and suicidal behaviour.

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