ISSN: 0172-780X | ISSN-L: 0172-780X | eISSN 2354-4716

www.nel.edu Editor-in-Chief: Peter G. Fedor-Freybergh

Neuro endo. lett. - 2006

Vol. 27 (Suppl 2) 2006 Neuro endocrinology letters

Cytochromes P450 reconstituted with NADPH: P450 reductase mimic the activating and detoxicating metabolism of the anticancer drug ellipticine in microsomes.

Kotrbová V, Aimová D, Brezinová A, Janouchová K, Poljaková J, Frei E, Stiborová M.

Evaluation Studies 2006; 27(Suppl 2): 18-22 PubMed PMID: 17159771 Keywords: Animals, Antineoplastic Agents:pharmacokinetics, Cytochrome P-450 Enzyme System:chemistry, DNA Adducts:metabolism, Ellipticines:pharmacokinetics, Metabolic Detoxication, Phase I, Microsomes, Liver:chemistry, Models, Biological, NADP:chemistry, NADPH-Ferri.

OBJECTIVES: Ellipticine is a potent antineoplastic agent exhibiting multiple action mechanisms. Recently, we found that after cytochrome P450 (CYP)-mediated oxidation ellipticine forms covalent DNA adducts. Ellipticine oxidation by isolated CYP and its binding to DNA is the target of this study.

METHODS: High per.....

Effect of galantamine on acetylcholinesterase and butyrylcholinesterase activities in the presence of L-carnitine in rat selected brain and peripheral tissues.

Svoboda Z, Kvetina J, Kunesová G, Herink J, Bajgar J, Bartosová L, Zivný P, Palicka V.

Journal Article 2006; 27(Suppl 2): 183-186 PubMed PMID: 17159811 Keywords: Acetylcholinesterase:blood, Animals, Brain:drug effects, Butyrylcholinesterase:blood, Carnitine:pharmacology, Cholinesterase Inhibitors:pharmacology, Galantamine:pharmacology, Liver:drug effects, Male, Pituitary Gland:drug effects, Rats, Rats, Wistar,.

Antilipoxygenase activity of copper complexes of aminoalkanoate type.

Ponist S, Valentová J, Bezáková L, Oblozinský M.

Journal Article 2006; 27(Suppl 2): 180-182 PubMed PMID: 17159810 Keywords: Animals, Copper:pharmacology, Fatty Acids, Unsaturated:metabolism, Lipoxygenase:metabolism, Lipoxygenase Inhibitors:pharmacology, Models, Biological, Organometallic Compounds:pharmacology, Rats,.

Cardiovascular toxicity of the first line cancer chemotherapeutic agents: doxorubicin, cyclophosphamide, streptozotocin and bevacizumab.

Drímal J, Zúrová-Nedelcevová J, Knezl V, Sotníková R, Navarová J.

Evaluation Studies 2006; 27(Suppl 2): 176-179 PubMed PMID: 17159809 Keywords: Animals, Antibodies, Monoclonal:adverse effects, Antibodies, Monoclonal, Humanized, Antineoplastic Agents:adverse effects, Bevacizumab, Cardiomyopathies:chemically induced, Chemokine CCL2:metabolism, Cyclophosphamide:adverse effects, Doxorubicin:adverse e.

Association between tissue gamma-glutamyl-transferase and clinical markers of adjuvant arthritis in Lewis rats.

Bauerová K, Ponist S, Ondrejicková O, Komendová D, Mihalová D.

Journal Article 2006; 27(Suppl 2): 172-175 PubMed PMID: 17159808 Keywords: Animals, Arthritis, Experimental:enzymology, Biomarkers:analysis, Body Weight:drug effects, Joints:enzymology, Male, Mannans:pharmacology, Rats, Rats, Inbred Lew, Spleen:enzymology, gamma-Glutamyltransferase:metabolism,.

Participation of reactive oxygen species in diabetes-induced endothelial dysfunction.

Zúrová-Nedelcevová J, Navarová J, Drábiková K, Jancinová V, Petríková M, Bernátová I, Kristová V, Snirc V, Nosál'ová V, Sotníková R.

Journal Article 2006; 27(Suppl 2): 168-171 PubMed PMID: 17159807 Keywords: Acetylcholine:pharmacology, Animals, Diabetes Mellitus, Experimental:complications, Diabetic Angiopathies:etiology, Hyperglycemia:complications, Male, Phenylephrine:pharmacology, Rats, Rats, Wistar, Reactive Oxygen Species:adverse effects, Streptozocin, V.

Effect of some antioxidants on sarcoplasmic reticulum Ca2+-ATPase activity from rabbit skeletal muscle.

Strosová M, Karlovská J, Galbavý P, Horáková L.

Journal Article 2006; 27(Suppl 2): 164-167 PubMed PMID: 17159806 Keywords: Animals, Antioxidants:pharmacology, Calcium:metabolism, Female, Flavonoids:pharmacology, Muscle, Skeletal:drug effects, Rabbits, Sarcoplasmic Reticulum Calcium-Transporting ATPases:metabolism,.

Effect of carvedilol on reactive oxygen species and enzymes linking innate and adaptive immunity.

Pecivová J, Macicková T, Lojek A, Gallová L, Cíz M, Nosál' R, Holománová D.

Journal Article 2006; 27(Suppl 2): 160-163 PubMed PMID: 17159805 Keywords: Animals, Carbazoles:pharmacology, Cells, Cultured, Immunity, Cellular:drug effects, Immunity, Innate:drug effects, Macrophages:drug effects, Mice, N-Formylmethionine Leucyl-Phenylalanine:pharmacology, Nitric Oxide Synthase Type II:metabolism, Peroxidase:m.

Content of protein carbonyl groups in gerbil brain after reversible bilateral carotid occlusion: effect of 2,3-dihydromelatonin.

Ondrejicková O, Rapková M, Snirc V, Dubovický M, Jariabka P, Zacharová S, Stolc S.

Journal Article 2006; 27(Suppl 2): 156-159 PubMed PMID: 17159804 Keywords: Animals, Arterial Occlusive Diseases:pathology, Brain Chemistry:drug effects, Carotid Arteries, Gerbillinae, Glutathione:analysis, Ischemic Attack, Transient:pathology, Male, Malondialdehyde:analysis, Melatonin:analogs & derivatives, Protein Carbonylation.

Ischaemia/reperfusion-induced organ injury in low dose streptozotocin diabetes.

Nosál'ová V, Drábiková K, Zúrová-Nedelcevová J, Jancinová V, Okruhlicová L, Nosál' R, Sotníková R.

Journal Article 2006; 27(Suppl 2): 152-155 PubMed PMID: 17159803 Keywords: Animals, Diabetes Mellitus, Experimental:complications, Diabetic Angiopathies:pathology, Dose-Response Relationship, Drug, Intestinal Diseases:complications, Intestine, Small:blood supply, Male, Mesenteric Artery, Superior:metabolism, Phenylephrine:pharma.

On the pharmacology and toxicology of neutrophils.

Nosál' R, Drábiková K, Jancinová V, Macicková T, Pecivová J, Holománová D.

Comparative Study 2006; 27(Suppl 2): 148-151 PubMed PMID: 17159802 Keywords: Benzothiepins:pharmacology, Histamine:pharmacology, Histamine H1 Antagonists:pharmacology, Humans, Loratadine:pharmacology, Neutrophils:drug effects, Peroxidase:metabolism, Superoxide Dismutase:metabolism, Tetradecanoylphorbol Acetate:pharmacology,.

Effect of acetylcholine and ischaemia/reperfusion injury on the heart of rats with STZ-induced experimental diabetes.

Knezl V, Kysel'ová Z, Zúrová-Nedelcevová J, Navarová J, Tribulová N, Drímal J.

Comparative Study 2006; 27(Suppl 2): 144-147 PubMed PMID: 17159801 Keywords: Acetylcholine:pharmacology, Animals, Diabetes Mellitus, Experimental:complications, Diabetic Angiopathies:complications, Evoked Potentials:drug effects, Heart:drug effects, Male, Myocardial Ischemia:complications, Rats, Rats, Wistar, Reperfusion Injury:co.

Extra- and intracellular formation of reactive oxygen species by human neutrophils in the presence of pheniramine, chlorpheniramine and brompheniramine.

Jancinová V, Drábiková K, Nosál' R, Holománová D.

Comparative Study 2006; 27(Suppl 2): 141-143 PubMed PMID: 17159800 Keywords: Brompheniramine:pharmacology, Chlorpheniramine:pharmacology, Extracellular Fluid:metabolism, Histamine H1 Antagonists:pharmacology, Humans, Intracellular Fluid:metabolism, Luminescence, Neutrophils:drug effects, Pheniramine:pharmacology, Reactive Oxygen S.

On the antioxidant activity of carvedilol in human polymorphonuclear leukocytes in vitro and ex vivo.

Drábiková K, Jancinová V, Nosál' R, Solík P, Murín J, Holománová D.

Clinical Trial 2006; 27(Suppl 2): 138-140 PubMed PMID: 17159799 Keywords: Adrenergic beta-Antagonists:pharmacology, Aged, Antihypertensive Agents:therapeutic use, Antioxidants:pharmacology, Carbazoles:pharmacology, Diabetes Mellitus, Type 2:blood, Diabetic Angiopathies:blood, Female, Heart Failure:blood, Humans, In Vitro Techni.

Autologous biograft and mesenchymal stem cells in treatment of the diabetic foot.

Vojtassák J, Danisovic L, Kubes M, Bakos D, Jarábek L, Ulicná M, Blasko M.

Clinical Trial 2006; 27(Suppl 2): 134-137 PubMed PMID: 17159798 Keywords: Aged, Cells, Cultured, Combined Modality Therapy, Diabetic Foot:surgery, Humans, Mesenchymal Stem Cell Transplantation:methods, Skin Transplantation:methods, Transplantation, Autologous, Wound Healing,.

Stereoselective determination of methadone and its main metabolite in serum and urine from methadone maintenance patients.

Valentová J, Horáková R, Pechová I, Okruhlica L, Devínsky F.

Journal Article 2006; 27(Suppl 2): 130-133 PubMed PMID: 17159797 Keywords: Adult, Chromatography, High Pressure Liquid:methods, Dose-Response Relationship, Drug, Female, Humans, Male, Methadone:analogs & derivatives, Molecular Conformation, Opioid-Related Disorders:blood, Sensitivity and Specificity,.

Detection and determination of abused hallucinogens in biological material.

Ondra P, Zedníková K, Válka I.

Evaluation Studies 2006; 27(Suppl 2): 125-129 PubMed PMID: 17159796 Keywords: Chromatography, Thin Layer, Forensic Toxicology:methods, Gas Chromatography-Mass Spectrometry, Hallucinogens:blood, Humans, Models, Biological, Substance Abuse Detection:methods,.

Simultaneous determination of amphetamines and amphetamine-derived designer drugs in human urine by GC-MS.

Maresová V, Chadt J, Prikryl L.

Evaluation Studies 2006; 27(Suppl 2): 121-124 PubMed PMID: 17159795 Keywords: Amphetamines:urine, Designer Drugs:analysis, Gas Chromatography-Mass Spectrometry:methods, Humans, Reproducibility of Results, Sensitivity and Specificity, Substance Abuse Detection:methods,.

Blood metallothionein, neuron specific enolase, and protein S100B in patients with traumatic brain injury.

Kukacka J, Vajtr D, Huska D, Průsa R, Houstava L, Samal F, Diopan V, Kotaska K, Kizek R.

Journal Article 2006; 27(Suppl 2): 116-120 PubMed PMID: 17159794 Keywords: Brain Injuries:blood, Gene Expression Profiling, Humans, Magnetic Resonance Imaging, Metallothionein:blood, Nerve Growth Factors:blood, Phosphopyruvate Hydratase:blood, Radiography, S100 Calcium Binding Protein beta Subunit, S100 Proteins:blood,.

Importance of diet in protection against oxidative damage.

Staruchová M, Volková K, Lajdová A, Misl'anová C, Collins A, Wsólová L, Staruch L, Dusinská M.

Comparative Study 2006; 27(Suppl 2): 112-115 PubMed PMID: 17159793 Keywords: Adult, Aged, Aged, 80 and over, DNA Damage, Diet, Female, Fruit, Humans, Male, Malondialdehyde:blood, Middle Aged, Mineral Fibers:toxicity, Occupational Diseases:prevention & control, Oxidative Stress, Vegetables, Vitamins:blood,.

Adverse effects of herbicide MCPA on dogs in a 90 day toxicological study.

Sadlonová I, Hózová R, Flaskárová E.

Evaluation Studies 2006; 27(Suppl 2): 108-111 PubMed PMID: 17159792 Keywords: 2-Methyl-4-chlorophenoxyacetic Acid:toxicity, Alanine Transaminase:blood, Alkaline Phosphatase:blood, Animals, Creatinine:blood, Dogs, Female, Herbicides:toxicity, Male, Organ Size:drug effects, Spermatogenesis:drug effects, Testis:anatomy & histology, To.

Evaluation of xenoestrogenic potential of propylparaben in zebrafish (Danio rerio).

Mikula P, Dobsíková R, Svobodová Z, Jarkovský J.

Comparative Study 2006; 27(Suppl 2): 104-107 PubMed PMID: 17159791 Keywords: Animals, Estrogens:toxicity, Parabens:toxicity, Preservatives, Pharmaceutical:toxicity, Toxicity Tests, Vitellogenins:analysis, Zebrafish,.

Genetic predisposition and health effect of occupational exposure to asbestos.

Horská A, Kazimírová A, Barancoková M, Wsólová L, Tulinská J, Dusinská M.

Comparative Study 2006; 27(Suppl 2): 100-103 PubMed PMID: 17159790 Keywords: Asbestos:toxicity, Asbestosis:genetics, Epoxide Hydrolases:genetics, Gene Frequency, Genetic Predisposition to Disease, Glutathione S-Transferase pi:genetics, Glutathione Transferase:genetics, Health, Humans, Micronuclei, Chromosome-Defective:chemically i.

Acute toxicity of magnetic nanoparticles in mice.

Gajdosíková A, Gajdosík A, Koneracká M, Závisová V, Stvrtina S, Krchnárová V, Kopcanský P, Tomasovicová N, Stolc S, Timko M.

Comparative Study 2006; 27(Suppl 2): 96-99 PubMed PMID: 17159789 Keywords: Animals, Drug Compounding, Female, Magnetics, Metal Nanoparticles:analysis, Mice, Mice, Inbred ICR, Polyesters:chemistry, Toxicity Tests,.

Effects of cypermethrin on some haematological, biochemical and histopathological parameters of common carp (Cyprinus carpio L.).

Dobsíková R, Velísek J, Wlasow T, Gomulka P, Svobodová Z, Novotný L.

Comparative Study 2006; 27(Suppl 2): 91-95 PubMed PMID: 17159788 Keywords: Alkaline Phosphatase:blood, Animals, Blood Cell Count, Blood Cells:drug effects, Butyrylcholinesterase:metabolism, Carps:anatomy & histology, Creatine Kinase:blood, Hyperplasia:chemically induced, Insecticides:toxicity, Lactic Acid:blood, Pancreas:patholo.

Simulation of radiation damage to lung cells after exposure to radon decay products.

Breier R, Böhm R, Kopáni M.

Comparative Study 2006; 27(Suppl 2): 86-90 PubMed PMID: 17159787 Keywords: Adult, Bystander Effect:radiation effects, Carcinoma:etiology, Computer Simulation, Humans, Lung:radiation effects, Lung Neoplasms:etiology, Models, Biological, Neoplasms, Radiation-Induced, Radon Daughters:toxicity, Risk Factors, Smoking:adverse effects,.

Neurobehavioural changes in rats after neonatal anoxia: effect of antioxidant stobadine pretreatment.

Ujházy E, Schmidtová M, Dubovický M, Navarova J, Brucknerová I, Mach M.

Evaluation Studies 2006; 27(Suppl 2): 82-85 PubMed PMID: 17159786 Keywords: Animals, Animals, Newborn, Antioxidants:therapeutic use, Behavior, Animal:drug effects, Carbolines:therapeutic use, Female, Growth and Development:drug effects, Hypoxia:pathology, Male, Motor Activity:drug effects, Pregnancy, Pregnancy, Animal, Premedicat.

Selected biochemical variables in a model of neonatal anoxia in rats.

Navarová J, Schmidtová M, Ujházy E, Dubovický M, Mach M.

Journal Article 2006; 27(Suppl 2): 78-81 PubMed PMID: 17159785 Keywords: Acetylglucosaminidase:analysis, Animals, Animals, Newborn, Biomarkers:analysis, Brain Chemistry, Disease Models, Animal, Female, Glutathione:analysis, Hypoxia:metabolism, Lactic Acid:analysis, Liver:chemistry, Lung:chemistry, Rats, Rats, Wistar,.

Czech Teratology Information Service: comparison of treatments by psychotropic and antiepileptic drugs.

Manáková E, Hubicková-Heringová L, Jelínek R.

Comparative Study 2006; 27(Suppl 2): 74-77 PubMed PMID: 17159784 Keywords: Anticonvulsants:adverse effects, Congenital Abnormalities:epidemiology, Czech Republic, Developmental Disabilities:chemically induced, Epilepsy:complications, Female, Fetal Death:chemically induced, Humans, Infant, Newborn, Information Services, Pregnancy.

Vitamin E supplementation in phenytoin induced developmental toxicity in rats: postnatal study.

Mach M, Dubovický M, Navarová J, Kovacovský P, Ujházy E.

Evaluation Studies 2006; 27(Suppl 2): 69-73 PubMed PMID: 17159783 Keywords: Animals, Animals, Newborn, Dietary Supplements, Female, Fetal Hypoxia:chemically induced, Fetal Viability:drug effects, Growth and Development:drug effects, Male, Phenytoin:toxicity, Pregnancy, Pregnancy, Animal, Prenatal Exposure Delayed Effects:preventi.

Delivery as a "physiological stress" and its influence on some parameters of oxidative stress.

Brucknerová I, Benedeková M, Pechán I, Holomán K, Bieliková E, Kostrová A, Ujházy E, Dubovický M, Mach M.

Comparative Study 2006; 27(Suppl 2): 65-68 PubMed PMID: 17159782 Keywords: Asphyxia Neonatorum:blood, Delivery, Obstetric, Glutathione Peroxidase:blood, Humans, Infant, Newborn, Malondialdehyde:blood, Oxidative Stress, Stress, Physiological:blood, Superoxide Dismutase:blood, Term Birth:blood,.

Testing of bacteria isolated from HIV/AIDS patients in experimental models.

Zajac V, Mego M, Martinický D, Stevurková V, Cierniková S, Ujházy E, Gajdosík A, Gajdosíková A.

Journal Article 2006; 27(Suppl 2): 61-64 PubMed PMID: 17159781 Keywords: Acquired Immunodeficiency Syndrome:microbiology, Animals, Bacteria:isolation & purification, Colon:microbiology, Colony Count, Microbial, Endocytosis, Female, HIV-1, HL-60 Cells, Humans, Male, Microbial Viability, Models, Biological, Rabbits,.

Chromosomal damage and polymorphisms of DNA repair genes XRCC1 and XRCC3 in workers exposed to cytostatics.

Musák L, Vodicka P, Klimentová G, Soucek P, Hánová M, Mikulková R, Buchancová J, Vodicková L, Poláková V, Péc M.

Journal Article 2006; 27(Suppl 2): 57-60 PubMed PMID: 17159780 Keywords: Adult, Antineoplastic Agents:toxicity, Chromosomes, Human, DNA Damage, DNA-Binding Proteins:genetics, Female, Gene Frequency, Genetic Predisposition to Disease, Humans, Male, Medical Staff, Hospital, Middle Aged, Occupational Diseases:chemically induced, .

Research on biomodulatory effect of natural compounds.

Miadoková E, Nadová S, Trebatická M, Grolmus J, Kopásková M, Rauko P, Mucaji P, Grancai D.

Evaluation Studies 2006; 27(Suppl 2): 53-56 PubMed PMID: 17159779 Keywords: Animals, Antimutagenic Agents:pharmacology, Antineoplastic Agents:pharmacology, Cell Proliferation:drug effects, Cell Survival:drug effects, Cisplatin:pharmacology, Cynara scolymus:chemistry, Drosophila melanogaster, Drug Synergism, Female, Male, Mice, Mu.

Anti-proliferative activity and apoptotic effect of tick salivary gland extracts on human HeLa cells.

Kazimírová M, Dovinová I, Rolníková T, Tóthová L, Hunáková L.

Comparative Study 2006; 27(Suppl 2): 48-52 PubMed PMID: 17159778 Keywords: Animals, Antineoplastic Agents:pharmacology, Apoptosis:drug effects, Cell Cycle:drug effects, Cell Proliferation:drug effects, Female, Guinea Pigs, HeLa Cells, Humans, Mice, Mice, Inbred ICR, Rabbits, Salivary Glands:chemistry, Ticks:chemistry, Tissue Ext.

Study of cytotoxic, genotoxic and DNA-protective effects of selected plant essential oils on human cells cultured in vitro.

Horváthová E, Sramková M, Lábaj J, Slamenová D.

Evaluation Studies 2006; 27(Suppl 2): 44-47 PubMed PMID: 17159777 Keywords: Caco-2 Cells, Cells, Cultured, Cytotoxins:pharmacology, DNA:drug effects, DNA Damage, Humans, Monoterpenes:pharmacology, Mutagenicity Tests, Plant Oils:pharmacology, Protective Agents:pharmacology, Thymol:pharmacology,.

Redox status and expression of chemokines in the rat lungs on exposure to asbestos and asbestos substituents.

Tátrai E, Brózik M, Kováciková Z.

Journal Article 2006; 27(Suppl 2): 40-43 PubMed PMID: 17159776 Keywords: Animals, Antioxidants:analysis, Asbestos:toxicity, Cell Survival:drug effects, Chemokine CCL2:metabolism, Chemokine CCL4, Chemokines:metabolism, Glutathione Peroxidase:analysis, Glutathione Reductase:analysis, Inhalation Exposure, Lung:chemistry, Macropha.

Modulation of CYP1A1-mediated oxidation of carcinogenic azo dye Sudan I and its binding to DNA by cytochrome b5.

Stiborová M, Martínek V, Schmeiser H, Frei E.

Journal Article 2006; 27(Suppl 2): 35-39 PubMed PMID: 17159775 Keywords: Animals, Coloring Agents:pharmacokinetics, Cytochrome P-450 CYP1A1:metabolism, Cytochromes b5:physiology, DNA:metabolism, DNA Adducts:metabolism, Humans, Male, Metabolic Detoxication, Phase I, Models, Biological, Naphthols:metabolism, Rabbits, Rats, Rats,.

The degradative action of peroxynitrite on high-molecular-weight hyaluronan.

Stankovská M, Hrabárová E, Valachová K, Molnárová M, Gemeiner P, Soltés L.

Comparative Study 2006; 27(Suppl 2): 31-34 PubMed PMID: 17159774 Keywords: Hyaluronic Acid:chemistry, Hydrogen Peroxide:pharmacology, Manganese Compounds:pharmacology, Models, Biological, Molecular Weight, Oxides:pharmacology, Peroxynitrous Acid:chemical synthesis, Viscosity,.

Experimental approaches to studies on drug metabolism and drug interactions in man: interaction of acyclic nucleoside phosphonates with human liver cytochromes P450 and flavin-containing monooxygenase 3.

Matal J, Orság J, Nekvindová J, Anzenbacherová E, Veinlichová A, Anzenbacher P, Zídek Z, Holý A.

Journal Article 2006; 27(Suppl 2): 27-30 PubMed PMID: 17159773 Keywords: Adenine:analogs & derivatives, Bacteria:ultrastructure, Cell Membrane:metabolism, Cytochrome P-450 Enzyme System:genetics, Drug Interactions, Humans, Liver:drug effects, Metabolic Detoxication, Phase I, Models, Biological, NADPH-Ferrihemoprotein Reductase.

Effect of exposure to ceramic fibres and cigarette smoke on antioxidant status of the lung.

Kováciková Z, Hurbánková M, Cerná S, Tátrai E, Beno M, Wimmerová S.

Evaluation Studies 2006; 27(Suppl 2): 23-26 PubMed PMID: 17159772 Keywords: Animals, Antioxidants:analysis, Body Weight:drug effects, Bronchoalveolar Lavage Fluid:chemistry, Ceramics:toxicity, Glutathione Peroxidase:analysis, Inhalation Exposure:analysis, Lung:chemistry, Lung Diseases:chemically induced, Male, Mineral Fibers:toxi.

Toxicological aspects of flavonoid interaction with biomacromolecules.

Hodek P, Hanustiak P, Krízková J, Mikelova R, Krízková S, Stiborová M, Trnková L, Horna A, Beklová M, Kizek R.

Journal Article 2006; 27(Suppl 2): 14-17 PubMed PMID: 17159770 Keywords: Adenine:metabolism, Animals, Colon:drug effects, Cytochrome P-450 CYP1A1:metabolism, DNA, Single-Stranded:metabolism, Electrochemistry, Enzyme Activation:drug effects, Flavonoids:metabolism, Guanidine:metabolism, Male, Microsomes, Liver:drug effects, Mode.

Oxidative detoxication of carcinogenic 2-nitroanisole by human, rat and rabbit cytochrome P450.

Dracínska H, Miksanová M, Svobodová M, Smrcek S, Frei E, Schmeiser H, Stiborová M.

Journal Article 2006; 27(Suppl 2): 9-13 PubMed PMID: 17159769 Keywords: Adolescent, Adult, Aged, Aniline Compounds:metabolism, Animals, Anisoles:pharmacokinetics, Carcinogens:pharmacokinetics, Child, Child, Preschool, Cytochrome P-450 Enzyme System:metabolism, Female, Humans, In Vitro Techniques, Male, Metabolic Detoxication,.