Vol. 29 (2) 2008 Neuro endocrinology letters

SUMO1 enhances 17-beta estradiol's effect on CRH promoter activation through estrogen receptors.

OBJECTIVES: Human corticotrophin-releasing hormone (CRH) plays a pivotal role in the stress response. Its expression is under the control of various steroid hormones, such as estrogens. The transcriptional activity of the estrogen receptor (ER) may be modified by small-ubiquitin related modifier (SUMO1). In the present study, we aim to .....