The effect of aldose reductase inhibition by JMC-2004 on hyperglycemia-induced endothelial dysfunction.
OBJECTIVES: An increased glucose utilization by aldose reductase (ALR-2) has been implicated in the pathogenesis of diabetic vascular complications. In this process, several mechanisms are involved, including the depletion of cofactors required for the action of antioxidant enzymes or endothelial NO synthase. In this study, the effect o.....