Effects of rosiglitazone--peroxisome proliferators-activated receptor gamma (PPARgamma) agonist on cell viability of human pituitary adenomas in vitro.

Winczyk K, Kunert-Radek J, Gruszka A, Radek M, Ławnicka H, Pawlikowski M.

Journal Article 2009; 30(1): 107-110 PubMed PMID: 19300395 Keywords: Acromegaly:etiology, Adenoma:complications, Adrenocorticotropic Hormone:secretion, Adult, Aged, Cell Proliferation:drug effects, Cell Survival:drug effects, Drug Evaluation, Preclinical, Female, Human Growth Hormone:secretion, Humans, Hypoglycemic Agents:.

OBJECTIVES: Rosiglitazone (RGZ) belongs to thiazolidinediones - new class of antidiabetic drugs which are PPARgamma agonists. It was shown that tumoral tissue, including the pituitary adenomas, posses PPARgamma receptors. The activation of PPARgamma receptors inhibits tumour growth in rodents and induces the oncostatic effect on human c.....

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Vol. 30 (1) 2009 Neuro endocrinology letters

Effects of rosiglitazone--peroxisome proliferators-activated receptor gamma (PPARgamma) agonist on cell viability of human pituitary adenomas in vitro.

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