Vol. 30 (1) 2009 Neuro endocrinology letters

Novel and simple behavioral paradigm for assessing anxiety in rats: effect of diazepam.

OBJECTIVES: Anxiety is an emotional state experienced by people, and is not readily modeled in animals. In order to extend till now ethologically derived paradigms used in the evaluation of anxiety and fear in rodents, a modified open-field was designed.

METHODS: Spontaneous behavior of male rats was investigated.....