Bradykinin receptors antagonists and nitric oxide synthase inhibitors in vincristine and streptozotocin induced hyperalgesia in chemotherapy and diabetic neuropathy rat model.

Bujalska M, Makulska-Nowak H.

Journal Article 2009; 30(1): 144-152 PubMed PMID: 19300402 Keywords: Animals, Bradykinin:administration & dosage, Bradykinin Receptor Antagonists, Diabetes Mellitus, Experimental:chemically induced, Diabetic Neuropathies:chemically induced, Drug Evaluation, Preclinical, Enzyme Inhibitors:administration & dosage, Hyperalges.

PURPOSE: The influence of an irreversible inhibitor of constitutive NO synthase (L-NOArg; 1.0 mg/kg ip), a relatively selective inhibitor of inducible NO synthase (L-NIL; 1.0 mg/kg ip) and a relatively specific inhibitor of neuronal NO synthase (7-NI; 0.1 mg/kg ip), on antihyperalgesic action of selective antagonists of B2 and B1 recept.....

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Vol. 30 (1) 2009 Neuro endocrinology letters

Bradykinin receptors antagonists and nitric oxide synthase inhibitors in vincristine and streptozotocin induced hyperalgesia in chemotherapy and diabetic neuropathy rat model.

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