Synergistic interaction between rilmenidine and ibuprofen in the writhing test in mice.
OBJECTIVES: The aim of the study was to ascertain whether rilmenidine, a second generation imidazoline-alpha-2-adrenoreceptor agonist, is able to increase analgesic effects of ibuprofen in the writhing test in mice. Experimental studies combining these agents have not yet been published.
METHODS: An acetic acid (.....