Diabetes mellitus decreases the expression of calcitonin-gene related peptide, gamma-amino butyric acid and glutamic acid decarboxylase in human pancreatic islet cells.

Al-Salam S, Hameed R, Parvez H, Adeghate E.

Journal Article 2009; 30(4): 506-510 PubMed PMID: 20010500 Keywords: Calcitonin Gene-Related Peptide:metabolism, Diabetes Mellitus, Type 2:metabolism, Fluorescent Antibody Technique, Glucagon:metabolism, Glutamate Decarboxylase:metabolism, Humans, Insulin:metabolism, Insulin-Secreting Cells:cytology, Pancreatectomy, Pancre.

OBJECTIVES: The pattern of distribution of calcitonin-gene related peptide (CGRP), a neuropeptide, gamma-aminobutyric acid (GABA), a neurotransmitter and GABA-converting enzyme, glutamic acid decarboxylase (GAD) in the pancreas of diabetic patients was investigated to determine whether diabetes mellitus influences the expression of thes.....

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Vol. 30 (4) 2009 Neuro endocrinology letters

Diabetes mellitus decreases the expression of calcitonin-gene related peptide, gamma-amino butyric acid and glutamic acid decarboxylase in human pancreatic islet cells.

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