Impact of repeated methamphetamine pretreatment on intravenous self-administration of the drug in males and estrogenized or non- estrogenized ovariectomized female rats.

Kucerova J, Vrskova D, Sulcova A.

Journal Article 2009; 30(5): 663-670 PubMed PMID: 20035259 Keywords: Animals, Behavior, Animal:drug effects, Central Nervous System Stimulants:administration & dosage, Estradiol:pharmacology, Female, Humans, Infusions, Intravenous, Male, Methamphetamine:administration & dosage, Ovariectomy, Rats, Rats, Wistar, Reinforcemen.

OBJECTIVE: The female animals were already recorded to respond differently to methamphetamine (MET) abuse than males. This gender dissimilarity may be caused by the influence of estral cycles and different susceptibility to behavioural sensitization.

METHODS: Influences of gender and pre-exposure to MET were stud.....

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Vol. 30 (5) 2009 Neuro endocrinology letters

Impact of repeated methamphetamine pretreatment on intravenous self-administration of the drug in males and estrogenized or non- estrogenized ovariectomized female rats.

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