Vol. 30 (Suppl 1) 2009 Neuro endocrinology letters

Evaluation of the activity of P450 enzymes in rats: use of the single marker or combined drug administration.

OBJECTIVES: A "cocktail" of several substrates is frequently used to assess metabolic activity of multiple cytochrome P450 enzymes in one session. Some interactions among substrates can appear and may influence the rate of biotransformation of other ones. Our current work was aimed on the influence of tolbutamide on cytochrome P450-medi.....