Estrogen receptor-alpha immunoreactivity in the arcuate hypothalamus of young and middle-aged female mice.
BACKGROUND: Changes in the neuroendocrine regulation of gonadal function, via altered hypothalamic sensitivity to peripheral hormones, are known to schedule reproductive maturation in the young and influence reproductive senescence. Estrogen (E) is a key hormone in this process. While changes in circulating levels of E over the life spa.....