Vol. 31 (Suppl 2) 2010 Neuro endocrinology letters

Role of cytochromes P450 and peroxidases in metabolism of the anticancer drug ellipticine: additional evidence of their contribution to ellipticine activation in rat liver, lung and kidney.

Stiborova M, Moserova M, Mrazova B, Kotrbova V, Frei E.

Journal Article 2010; 31(Suppl 2): 26-35 PubMed PMID: 21187821 Citation  Keywords:  Animals, Antineoplastic Agents:metabolism, Biotransformation:drug effects, Cytochrome P-450 Enzyme System:physiology, DNA Adducts:drug effects, Ellipticines:metabolism, Kidney:metabolism, Liver:metabolism, Lung:metabolism, Male, Microsomes:drug effects, M.

OBJECTIVE: Ellipticine is a potent antineoplastic agent exhibiting multiple mechanisms of action. This anticancer agent should be considered a pro-drug, whose pharmacological efficiency and/or genotoxic side effects are dependent on its cytochrome P450 (CYP)- and/or peroxidase-mediated activation to species forming covalent DNA adducts......

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Ascorbate and Cu(II)-induced oxidative degradation of high-molar-mass hyaluronan. Pro- and antioxidative effects of some thiols.

Valachova K, Hrabarova E, Drafi F, Juranek I, Bauerova K, Priesolova E, Nagy M, Soltes L.
Journal Article 2010; 31(Suppl 2): 101-104 PubMed PMID: 21187839 Citation  Keywords:  Antioxidants:pharmacology, Ascorbic Acid:pharmacology, Copper:pharmacology, Cysteamine:pharmacology, Dose-Response Relationship, Drug, Glutathione:pharmacology, Hyaluronic Acid:metabolism, Hydrogen Peroxide:metabolism, Hydroxides:metabolism, Oxidation-Red.

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Caco-2 cell monolayer integrity and effect of probiotic Escherichia coli Nissle 1917 components.

Stetinova V, Smetanova L, Kvetina J, Svoboda Z, Zidek Z, Tlaskalova-Hogenova H.
Journal Article 2010; 31(Suppl 2): 51-56 PubMed PMID: 21187838 Citation  Keywords:  Adenocarcinoma:metabolism, Caco-2 Cells, Carbon Radioisotopes, Cell Membrane Permeability:drug effects, Cell Survival:drug effects, Colonic Neoplasms:metabolism, Dose-Response Relationship, Drug, Escherichia coli, Humans, Lipopolysaccharides:pharmacology,.

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Carnosine inhibits degradation of hyaluronan induced by free radical processes in vitro and improves the redox imbalance in adjuvant arthritis in vivo.

Drafi F, Bauerova K, Valachova K, Ponist S, Mihalova D, Juranek I, Boldyrev A, Hrabarova E, Soltes L.
Journal Article 2010; 31(Suppl 2): 96-100 PubMed PMID: 21187837 Citation  Keywords:  Animals, Antioxidants:pharmacology, Antirheumatic Agents:pharmacology, Arthritis, Experimental:drug therapy, Carnosine:pharmacology, Disease Models, Animal, Free Radicals, Glutathione:metabolism, Hyaluronic Acid:metabolism, In Vitro Techniques, Male, Meth.

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Cytotoxic and genotoxic effect of methanolic flower extract from Gentiana asclepiadea on COS 1 cells.

Hudecova A, Hasplova K, Miadokova E, Magdolenova Z, Rinna A, Galova E, Sevcovicova A, Vaculcikova D, Gregan F, Dusinska M.
Journal Article 2010; 31(Suppl 2): 21-25 PubMed PMID: 21187836 Citation  Keywords:  Animals, Apoptosis:drug effects, COS Cells, Cercopithecus aethiops, Cytotoxins:pharmacology, DNA Damage:drug effects, Dose-Response Relationship, Drug, Flowers, Gentiana, Kidney:cytology, Models, Animal, Mutagens:pharmacology, Plant Extracts:pharmacology,.

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Different effect of two synthetic coumarin-stilbene hybrid compounds on phagocyte activity.

Drabikova K, Perecko T, Nosal R, Rackova L, Ambrozova G, Lojek A, Smidrkal J, Harmatha J, Jancinova V.
Journal Article 2010; 31(Suppl 2): 73-78 PubMed PMID: 21187835 Citation  Keywords:  Adult, Animals, Cell Line, Coumarins:pharmacology, Humans, Lipopolysaccharides:pharmacology, Macrophages:cytology, Male, Mice, Middle Aged, Models, Animal, Neutrophils:cytology, Nitric Oxide:metabolism, Phagocytosis:drug effects, Reactive Oxygen Species:m.

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Effects of high dietary levels of Se-enriched yeast on tissues selenium content and meat quality traits - a model study in rats.

Fajt Z, Modra H, Banoch T, Blahova J, Salakova A, Steinhauserova I, Svoboda M.
Journal Article 2010; 31(Suppl 2): 114-119 PubMed PMID: 21187833 Citation  Keywords:  Animal Feed, Animals, Dose-Response Relationship, Drug, Female, Lipid Metabolism:drug effects, Liver:drug effects, Malondialdehyde:metabolism, Meat, Models, Animal, Muscle, Skeletal:drug effects, Rats, Rats, Wistar, Selenium:metabolism, Yeasts,.

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Effects of probiotic Escherichia coli Nissle 1917 on expression of cytochromes P450 along the gastrointestinal tract of male rats.

Matuskova Z, Tunkova A, Anzenbacherova E, Vecera R, Siller M, Tlaskalova-Hogenova H, Zidek Z, Anzenbacher P.
Journal Article 2010; 31(Suppl 2): 46-50 PubMed PMID: 21187832 Citation  Keywords:  Animals, Aryl Hydrocarbon Hydroxylases:metabolism, Colon:enzymology, Cytochrome P-450 CYP3A:metabolism, Cytochrome P-450 Enzyme System:metabolism, Duodenum:enzymology, Escherichia coli, Gastrointestinal Tract:enzymology, Male, Models, Animal, Probiotics:p.

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Effects of subchronic exposure to Spartakus (prochloraz) on common carp Cyprinus carpio.

Haluzova I, Modra H, Blahova J, Marsalek P, Siroka Z, Groch L, Svobodova Z.
Journal Article 2010; 31(Suppl 2): 105-113 PubMed PMID: 21187831 Citation  Keywords:  Animals, Carps:metabolism, Ceruloplasmin:metabolism, Cytochrome P-450 CYP1A1:metabolism, Cytochrome P-450 Enzyme System:metabolism, Dose-Response Relationship, Drug, Fungicides, Industrial:pharmacology, Gills:drug effects, Glutathione:metabolism, Glutathi.

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Embryotoxicity of mirtazapine: a study using Chick Embryotoxicity Screening Test.

Manakova E, Hubickova L, Kostalova J, Zemanova Z.
Journal Article 2010; 31(Suppl 2): 8-10 PubMed PMID: 21187830 Citation  Keywords:  Abnormalities, Drug-Induced:epidemiology, Animals, Antidepressive Agents, Tricyclic:adverse effects, Chick Embryo:drug effects, Depression:drug therapy, Dose-Response Relationship, Drug, Embryonic Development:drug effects, Female, Humans, Mianserin:advers.

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Formation of reactive oxygen and nitrogen species in the presence of pinosylvin - an analogue of resveratrol.

Jancinova V, Nosal R, Lojek A, Ciz M, Ambrozova G, Mihalova D, Bauerova K, Harmatha J, Perecko T.
Journal Article 2010; 31(Suppl 2): 79-83 PubMed PMID: 21187828 Citation  Keywords:  Animals, Antioxidants:pharmacology, Antirheumatic Agents:therapeutic use, Arthritis, Experimental:drug therapy, Cell Line, Disease Models, Animal, Drug Therapy, Combination, Macrophages:cytology, Male, Methotrexate:therapeutic use, Neutrophils:drug effect.

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Identification of rat cytochromes P450 metabolizing N-(2-methoxyphenyl)hydroxylamine, a human metabolite of the environmental pollutants and carcinogens o-anisidine and o-nitroanisole.

Naiman K, Frei E, Stiborova M.
Journal Article 2010; 31(Suppl 2): 36-45 PubMed PMID: 21187827 Citation  Keywords:  Aniline Compounds:metabolism, Animals, Anisoles:metabolism, Aryl Hydrocarbon Hydroxylases:physiology, Carcinogens:metabolism, Cytochrome P-450 CYP2E1:physiology, Cytochrome P-450 Enzyme System:physiology, Environmental Pollutants:metabolism, Hydroxylamine.

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In vivo effect of pinosylvin and pterostilbene in the animal model of adjuvant arthritis.

Macickova T, Drabikova K, Nosal R, Bauerova K, Mihalova D, Harmatha J, Pecivova J.
Journal Article 2010; 31(Suppl 2): 91-95 PubMed PMID: 21187826 Citation  Keywords:  Animals, Anti-Inflammatory Agents:pharmacology, Antioxidants:pharmacology, Arthritis, Experimental:drug therapy, Disease Models, Animal, Dose-Response Relationship, Drug, Drug Therapy, Combination, Male, Oxidative Stress:drug effects, Peroxidase:metabolis.

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Modulation of ionising radiation generated oxidative stress by HI-6 (asoxime) in a laboratory rat model.

Pohanka M, Pejchal J, Horackova S, Kuca K, Bandouchova H, Damkova V, Pikula J.
Evaluation Studies 2010; 31(Suppl 2): 62-68 PubMed PMID: 21187825 Citation  Keywords:  Animals, Antidotes:pharmacology, Antioxidants:pharmacology, Glutathione Reductase:metabolism, Liver:drug effects, Male, Models, Animal, Oxidative Stress:drug effects, Oximes:pharmacology, Pyridinium Compounds:pharmacology, Radiation, Ionizing, Rats, Rats,.

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Molecular targets of the natural antioxidant pterostilbene: effect on protein kinase C, caspase-3 and apoptosis in human neutrophils in vitro.

Perecko T, Drabikova K, Rackova L, Ciz M, Podborska M, Lojek A, Harmatha J, Smidrkal J, Nosal R, Jancinova V.
Journal Article 2010; 31(Suppl 2): 84-90 PubMed PMID: 21187824 Citation  Keywords:  Antioxidants:pharmacology, Apoptosis:drug effects, Caspase 3:metabolism, Cell Survival:drug effects, Computer Simulation, Dose-Response Relationship, Drug, Humans, In Vitro Techniques, Male, Neutrophils:cytology, Phosphorylation:drug effects, Protein Kina.

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Pharmacokinetics and organ distribution of fluorescein in experimental pigs: an input study for confocal laser endomicroscopy of the gastrointestinal tract.

Kunes M, Kvetina J, Malakova J, Bures J, Kopacova M, Rejchrt S.
Journal Article 2010; 31(Suppl 2): 57-61 PubMed PMID: 21187822 Citation  Keywords:  Adipose Tissue:cytology, Animals, Blood-Brain Barrier, Brain:cytology, Female, Fluorescein:administration & dosage, Fluorescent Dyes:administration & dosage, Gastrointestinal Tract:cytology, Injections, Intravenous, Kidney:cytology, Lung:cytology, Microsc.

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Suppression of oxidative burst in human neutrophils with the naturally occurring serotonin derivative isomer from Leuzea carthamoides.

Nosal R, Perecko T, Jancinova V, Drabikova K, Harmatha J, Svitekova K.
Journal Article 2010; 31(Suppl 2): 69-72 PubMed PMID: 21187819 Citation  Keywords:  Adult, Carcinogens:pharmacology, Dose-Response Relationship, Drug, Humans, Leuzea, Male, Middle Aged, Neutrophils:drug effects, Oxidative Stress:drug effects, Phosphorylation:drug effects, Plant Extracts:pharmacology, Protein Kinase C:metabolism, Reactive.

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