Vol. 32 (6) 2011 Neuro endocrinology letters

Estrogen altered facial mechanical pain threshold and trigeminal P2X3 receptor expression.

OBJECTIVES: P2X3 receptors are expressed in trigeminal ganglia (TG) and participate in the transduction of facial pain. However, the mechanisms underlying P2X receptor-mediated nociception at different estrogen levels has not been examined.

METHODS: In this study, female rats were randomly divided into sham-opera.....