Vol. 33 (7) 2012 Neuro endocrinology letters

Early and late stage of neurodegeneration induced by trimethyltin in hippocampus and cortex of male Wistar rats.

BACKGROUND: Trimethyltin (TMT), a potent neurotoxicant, elicits neuronal death in the limbic system and causes damage particularly in the hippocampus. Current interest relates to the opportunity to use TMT as an experimental model of neurodegeneration in the study of Alzheimer-like diseases.

OBJECTIVE: In light o.....