Brain aging and testosterone-induced neuroprotection: studies on cultured sheep cortical neurons.
OBJECTIVE: This research reports the expression of topoisomerase βII in fetal sheep neuronal cells. The β isoform of DNA topoisomerase II plays a role in DNA repair process in non proliferating cells as neurons and its expression tends to be downregulated with senescence.
METHODS: Cortical neurons from 60-day-o.....