Vol. 34 (5) 2013 Neuro endocrinology letters

Brain aging and testosterone-induced neuroprotection: studies on cultured sheep cortical neurons.

OBJECTIVE: This research reports the expression of topoisomerase βII in fetal sheep neuronal cells. The β isoform of DNA topoisomerase II plays a role in DNA repair process in non proliferating cells as neurons and its expression tends to be downregulated with senescence.

METHODS: Cortical neurons from 60-day-o.....