Vol. 34 (Suppl 2) 2013 Neuro endocrinology letters

Oxidation of carcinogenic benzo[a]pyrene by human and rat cytochrome P450 1A1 and its influencing by cytochrome b5 - a comparative study.

Indra R, Moserova M, Sulc M, Frei E, Stiborova M.

Comparative Study 2013; 34(Suppl 2): 55-63 PubMed PMID: 24362093 Citation  Keywords:  Animals, Benzo(a)pyrene:metabolism, Carcinogens:metabolism, Cytochrome P-450 CYP1A1:metabolism, Cytochromes b5:pharmacology, Humans, Inactivation, Metabolic, Male, Microsomes, Liver:drug effects, Oxidation-Reduction, Rats,.

OBJECTIVES: Cytochrome P450 (CYP) 1A1 is the most important enzyme in both activation and detoxification of carcinogenic benzo[a]pyrene (BaP), in combination with microsomal epoxide hydrolase (mEH). To evaluate metabolism of BaP in human, identification of a suitable animal model that mimics the metabolic fate of BaP in human is of grea.....

Read abstract

Yew poisoning of olive baboons (Papio anubis) in captivity: laboratory diagnosis.

Kominkova M, Stanisavljevic M, Zitka O, Mazanek S, Sedlackova J, Bandouchova H, Pikula J, Beklova M, Kizek R.
Case Reports 2013; 34(Suppl 2): 130-133 PubMed PMID: 24362105 Citation  Keywords:  Alkaloids:analysis, Animals, Animals, Zoo, Bile:chemistry, Blood Chemical Analysis:veterinary, Clinical Laboratory Techniques, Fatal Outcome, Female, Foodborne Diseases:diagnosis, Male, Monkey Diseases:diagnosis, Papio anubis:blood, Taxoids:analysis, Taxu.

Read abstract  Full text PDF

Molecular biology of beta-estradiol-estrogen receptor complex binding to estrogen response element and the effect on cell proliferation.

Heger Z, Zitka O, Krizkova S, Beklova M, Kizek R, Adam V.
Journal Article 2013; 34(Suppl 2): 123-129 PubMed PMID: 24362104 Citation  Keywords:  Animals, Cell Proliferation:drug effects, Estradiol:metabolism, Gene Expression Regulation:drug effects, Humans, Male, Protein Binding:drug effects, Receptors, Estrogen:metabolism, Response Elements:drug effects,.

Read abstract  Full text PDF

Oxidative stress parameters in fish after subchronic exposure to acetylsalicylic acid.

Zivna D, Plhalova L, Praskova E, Stepanova S, Siroka Z, Sevcikova M, Blahova J, Bartoskova M, Marsalek P, Skoric M, Svobodova Z.
Journal Article 2013; 34(Suppl 2): 116-122 PubMed PMID: 24362103 Citation  Keywords:  Animals, Antioxidants:metabolism, Aspirin:toxicity, Behavior, Animal:drug effects, Environmental Exposure, Fishes:metabolism, Glutathione Transferase:metabolism, Lipid Peroxidation:drug effects, Oxidative Stress:drug effects, Thiobarbituric Acid Reactive .

Read abstract  Full text PDF

Biochemical markers for the assessment of pollution of selected small streams in the Czech Republic.

Zelníckova L, Blahova J, Marsalek P, Hostovsky M, Sevcikova M, Dobsikova R, Siroka Z, Divisova L, Plhalova L, Svobodova Z.
Journal Article 2013; 34(Suppl 2): 109-115 PubMed PMID: 24362102 Citation  Keywords:  Animals, Biomarkers:analysis, Brain:drug effects, Cytochrome P-450 CYP1A1:metabolism, Cytochrome P-450 Enzyme System:metabolism, Czech Republic, Environmental Monitoring:methods, Fishes:blood, Gills:chemistry, Glutathione Transferase:metabolism, Kidney:ch.

Read abstract  Full text PDF

Evaluation of ibuprofen toxicity for zebrafish (Danio rerio) targeting on selected biomarkers of oxidative stress.

Bartoskova M, Dobsikova R, Stancova V, Zivna D, Blahova J, Marsalek P, Zelníckova L, Bartos M, di Tocco F, Faggio C.
Journal Article 2013; 34(Suppl 2): 102-108 PubMed PMID: 24362101 Citation  Keywords:  Animals, Anti-Inflammatory Agents, Non-Steroidal:toxicity, Biomarkers:metabolism, Catalase:metabolism, Dose-Response Relationship, Drug, Glutathione Peroxidase:metabolism, Glutathione Reductase:metabolism, Glutathione Transferase:metabolism, Ibuprofen:tox.

Read abstract  Full text PDF

The effects of atrazine exposure on early life stages of common carp (Cyprinus carpio).

Chromcova L, Blahova J, Plhalova L, Zivna D, Stepanova S, Praskova E, Prokes M, Zelníckova L, Skoric M, Svobodova Z.
Journal Article 2013; 34(Suppl 2): 95-101 PubMed PMID: 24362100 Citation  Keywords:  Animals, Atrazine:toxicity, Carps:growth & development, Catalase:metabolism, Environmental Exposure:adverse effects, Glutathione Peroxidase:metabolism, Glutathione Reductase:metabolism, Herbicides:toxicity, Life Cycle Stages:drug effects, Lipid Peroxidati.

Read abstract  Full text PDF

Total mercury content in canine hair before and after administration of vaccines containing thiomersal.

Sedlackova L, Kral T, Sevcikova M, Kruzikova K, Svobodova Z.
Journal Article 2013; 34(Suppl 2): 90-94 PubMed PMID: 24362099 Citation  Keywords:  Animal Feed, Animals, Dogs, Female, Fishes, Food Contamination, Hair:chemistry, Male, Mercury:analysis, Preservatives, Pharmaceutical:administration & dosage, Thimerosal:administration & dosage, Vaccines:administration & dosage,.

Read abstract  Full text PDF

The effects of mycotoxin deoxynivalenol (DON) on haematological and biochemical parameters and selected parameters of oxidative stress in piglets.

Modra H, Blahova J, Marsalek P, Banoch T, Fictum P, Svoboda M.
Journal Article 2013; 34(Suppl 2): 84-89 PubMed PMID: 24362098 Citation  Keywords:  Animal Feed, Animals, Animals, Newborn, Biomarkers:blood, Blood Proteins:metabolism, Female, Food Contamination, Male, Mycotoxins:pharmacology, Oxidative Stress:drug effects, Swine, Trichothecenes:pharmacology,.

Read abstract  Full text PDF

Impact of paraoxon followed by acetylcholinesterase reactivator HI-6 on gastric myoelectric activity in experimental pigs.

Bures J, Kvetina J, Pavlik M, Kunes M, Kopacova M, Rejchrt S, Jun D, Hrabinova M, Kuca K, Tachecí I.
Journal Article 2013; 34(Suppl 2): 79-83 PubMed PMID: 24362097 Citation  Keywords:  Animals, Cholinesterase Reactivators:administration & dosage, Electromyography, Female, Heart Rate:drug effects, Injections, Intramuscular, Models, Animal, Oximes:administration & dosage, Paraoxon:administration & dosage, Pyridinium Compounds:administrati.

Read abstract  Full text PDF

Intravenous application of HI-6 salts (dichloride and dimethansulphonate) in pigs: comparison with pharmacokinetics profile after intramuscular administration.

Zdarova Karasova J, Zemek F, Kunes M, Kvetina J, Chladek J, Jun D, Bures J, Tachecí I, Kuca K.
Comparative Study 2013; 34(Suppl 2): 74-78 PubMed PMID: 24362096 Citation  Keywords:  Absorption, Animals, Biological Availability, Chlorides:administration & dosage, Cholinesterase Reactivators:administration & dosage, Female, Injections, Intramuscular, Injections, Intravenous, Oximes:administration & dosage, Pyridinium Compounds:administ.

Read abstract  Full text PDF

The effect of benzo[a]pyrene on metabolic activation of anticancer drug ellipticine in mice.

Stiborova M, Cerna V, Moserova M, Arlt V, Frei E.
Journal Article 2013; 34(Suppl 2): 43-54 PubMed PMID: 24362092 Citation  Keywords:  Animals, Antineoplastic Agents:pharmacokinetics, Benzo(a)pyrene:pharmacology, Biotransformation:drug effects, Cytochrome P-450 CYP1A1:metabolism, Cytochrome P-450 CYP1A2:metabolism, Cytochrome P-450 Enzyme System:metabolism, Drug Evaluation, Preclinical, .

Read abstract  Full text PDF

Trends in CNS affecting drugs in the calls to the Toxicological Information Center from 1997 to 2012.

Urban M, Navratil T, Pelclova D.
Journal Article 2013; 34(Suppl 2): 25-30 PubMed PMID: 24362089 Citation  Keywords:  Adolescent, Adult, Central Nervous System Agents:poisoning, Czech Republic:epidemiology, Databases, Factual, Drug Overdose:epidemiology, Drug-Related Side Effects and Adverse Reactions:diagnosis, Female, Humans, Information Centers:statistics & numerical .

Read abstract  Full text PDF

Biochemical and histopathological responses of Wistar rats to oral intake of microcystins and cyanobacterial biomass.

Adamovsky O, Palikova M, Ondrackova P, Zikova A, Kopp R, Mares J, Pikula J, Paskerova H, Kohoutek J, Blaha L.
Journal Article 2013; 34(Suppl 2): 11-20 PubMed PMID: 24362087 Citation  Keywords:  Animals, Carcinogens:toxicity, Cyanobacteria:chemistry, Food Chain, Kidney:drug effects, Liver:drug effects, Male, Microcystins:toxicity, Rats, Rats, Wistar, Spleen:drug effects,.

Read abstract  Full text PDF