Levothyroxine replacement therapy with vitamin E supplementation prevents the oxidative stress and apoptosis in hippocampus of hypothyroid rats.

Guo Y, Wan S, Zhong X, Zhong M, Pan T.

Journal Article 2014; 35(8): 684-690 PubMed PMID: 25702296 Keywords: Animals, Apoptosis:drug effects, Dietary Supplements, Disease Models, Animal, Drug Therapy, Combination, Hippocampus:drug effects, Hormone Replacement Therapy, Hypothyroidism:drug therapy, Male, Oxidative Stress:drug effects, Random Allocation, Rats.Rats.

OBJECTIVE: To examine the effect of levothyroxine (L-T4), vitamin E or both on oxidative stress status and hippocampal apoptosis in a propylthiouracil (PTU)-induced hypothyroid rat model.

METHODS: Sprague-Dawley rats were randomly divided into five groups: Control, PTU+PTU+L-T4+PTU+Vit E, PTU+Vit E+L-T4. In each .....

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Vol. 35 (8) 2014 Neuro endocrinology letters

Levothyroxine replacement therapy with vitamin E supplementation prevents the oxidative stress and apoptosis in hippocampus of hypothyroid rats.

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