A study on 17alpha-ethinylestradiol metabolism in rat and Pleurotus ostreatus.
OBJECTIVES: 17α-Ethinylestradiol (EE2) is an endocrine disruptor that is an ingredient of oral contraceptives. Here, EE2 metabolism catalyzed by cytochromes P450 (CYP) was studied. Two model organisms, rat and ligninolytic fungus Pleurotus ostreatus, were used.
METHODS: To resolve the role of rat and/or fungal C.....