Influence of p-glycoprotein on brain Bcl-2 family proteins and cytokines in transient cerebral ischemia.
OBJECTIVES: P-glycoprotein (P-gp), produced by the multidrug resistance (mdr1a) gene, is present in vascular endothelial cells, astrocytes, and microglia in the brain. We previously reported that P-gp aggravated cerebral infarct. Therefore, modulation of the function of P-gp is important for the treatment of brain ischemia. Her.....