Association between single nucleotide polymorphisms in non-coding regions of the insulin (INS) gene and schizophrenia.
OBJECTIVES: Schizophrenia is a psychotic disorder with high heritability. There are also indications that impaired cellular signalling via the insulin receptor-A and the insulin-like growth factor 1 receptor may play a role in its pathogenesis. Insulin, and possibly also C-peptide, are ligands to these receptors. The insulin gene, codin.....