Effects of tau on Aβ-induced synaptic damage in a Drosophila model of Alzheimer's disease.
OBJECTIVES: The etiology and pathologic mechanism underlying Alzheimer's disease (AD) are not clear. This study determined the effects of tau on amyloid-beta peptide(Aβ)-induced synaptic damages in a Drosophila model of AD. METHODS: Galactose-regulated upstream promoter element 4(Gal4) and an upstream active sequence syste.....