: Chlamydia pneumoniae (C. pneumoniae) is an obligate intracellular bacterial pathogen, which has long been investigated as a potential developmental or exacerbating factor in various pathologies. C. pneumoniae infects mainly the respiratory tract, but also has been associated with extrarespiratory manifestations. We report on an uncommon case of young patient with acute acalculous cholecystitis (AAC) and acute pericarditis during the chlamydia pneumoniae infection with hematogenous / lymphogenous routes of systemic dissemination of Chlamydia pneumoniae infection.