: Prevention of environment- and gene-dependent, teratogenic malfunctions ("Functional Teratogenesis")-- caused by abnormal hormone, neurotransmitter and cytokine concentrations during organization of the neuro-endocrine-immune system (NEIS) should be considered as a global challenge of outstanding relevance. By optimizing the natural and social environment and correcting in time abnormal concentrations of hormones, neurotransmitters and cytokines during the critical perinatal (pre- and early postnatal) organization period of the NEIS ("Neuro-Endocrine-Immune Prophylaxis") human ontogenesis and sociogenesis can be decisively improved ("Primary Prevention of Maldevelopments of Human Beings and their Societies"). Finally, phylogenesis is dependent on incessant sequencies of ontogenesis and sociogenesis ("Onto-Socio-Phylogenesis").