Articles by author - Zdenĕk Fisar

Plasma homocysteine in Alzheimer's disease with or without co-morbid depressive symptoms.

Kitzlerová E, Fisar Z, Jirák R, Zvĕrová M, Hroudová J, Benaková H, Raboch J.

Comparative Study 2014; 35(1): 42-49 PubMed PMID: 24625917  Keywords:  Age Factors, Aged, Aged, 80 and over, Alzheimer Disease:blood, Biomarkers:blood, Comorbidity, Depressive Disorder:blood, Female, Homocysteine:blood, Humans, Male, Middle Aged, Severity of Illness Index,.    Citation

OBJECTIVE: Elevated homocysteine is associated with a variety of diseases, including Alzheimer's disease (AD) and depressive disorder. Thi.....

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In vitro effects of acetylcholinesterase inhibitors and reactivators on Complex I of electron transport chain.

Hroudová J, Fisar Z, Korábečný J, Kuča K.

Journal Article 2011; 32(3): 259-263 PubMed PMID: 21712782  Keywords:  Animals, Brain Chemistry:drug effects, Cholinesterase Inhibitors:pharmacology, Cholinesterase Reactivators:pharmacology, Electron Transport:drug effects, Electron Transport Chain Complex Proteins:antagonists & inhibitors, Electron Transport Complex I:meta.    Citation

OBJECTIVES: Inhibition of the enzyme acetylcholinesterase (AChE) is the main mechanism both of therapeutic action of drugs for the treatme.....

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Inhibition of monoamine oxidase activity by antidepressants and mood stabilizers.

Fisar Z, Hroudová J, Raboch J.

Journal Article 2010; 31(5): 645-656 PubMed PMID: 21200377  Keywords:  Affect:drug effects, Amitriptyline:pharmacology, Animals, Antidepressive Agents:pharmacology, Antimanic Agents:pharmacology, Benzodiazepines:pharmacology, Cerebral Cortex:cytology, Citalopram:pharmacology, Clorgyline:pharmacology, Cocaine:pharmacology, Cy.    Citation

OBJECTIVE: Monoamine oxidase (MAO), the enzyme responsible for metabolism of monoamine neurotransmitters, has an important role in the bra.....

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Activities of respiratory chain complexes and citrate synthase influenced by pharmacologically different antidepressants and mood stabilizers.

Hroudova J, Fisar Z.

Comparative Study 2010; 31(3): 336-342 PubMed PMID: 20588251  Keywords:  Animals, Antidepressive Agents:pharmacology, Antipsychotic Agents:pharmacology, Benzodiazepines:pharmacology, Cerebral Cortex:drug effects, Citrate (si)-Synthase:metabolism, Electron Transport:drug effects, Electron Transport Complex I:metabolism, Electro.    Citation

OBJECTIVE: Mitochondrial dysfunctions, impaired bioenergetics and dysfunction of neurotrophins are included in many neurodegenerative and .....

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Distribution of antidepressants between plasma and red blood cells.

Fisar Z, Fuksová K, Sikora J, Kalisová L, Velenovská M, Novotná M.

Clinical Trial 2006; 27(3): 307-313 PubMed PMID: 16816836  Keywords:  Antidepressive Agents, Second-Generation:blood, Antidepressive Agents, Tricyclic:blood, Erythrocyte Membrane:drug effects, Female, Humans, Male, Neurotransmitter Uptake Inhibitors:blood, Plasma:metabolism, Reference Values, Structure-Activity Relationship.    Citation

OBJECTIVE: The distribution of different antidepressants between plasma and red blood cells (RBCs) or between water and erythrocyte membra.....

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