Articles by author - Eva Frei

Human cytochromes P450 1A1 and 1A2 participate in detoxication of carcinogenic aristolochic acid.

Sistkova J, Hudecek J, Hodek P, Frei E, Schmeiser H, Stiborova M.

Journal Article 2008; 29(5): 733-737 PubMed PMID: 18987598  Keywords:  Animals, Aristolochic Acids:pharmacokinetics, Carcinogens:pharmacokinetics, Chromatography, High Pressure Liquid, Cytochrome P-450 CYP1A1:isolation & purification, Cytochrome P-450 CYP1A2:isolation & purification, Humans, Inactivation, Metabolic, Mice, Mi.    Citation

OBJECTIVES: A carcinogenic and nephrotoxic plant alkaloid, aristolochic acid (AA), causes the development of aristolochic acid nephropathy.....

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Isolation and partial characterization of the adduct formed by 13-hydroxyellipticine with deoxyguanosine in DNA.

Moserova M, Kotrbova V, Rupertova M, Naiman K, Hudecek J, Hodek P, Frei E, Stiborova M.

Journal Article 2008; 29(5): 728-732 PubMed PMID: 18987592  Keywords:  Acetyl Coenzyme A:metabolism, Arylamine N-Acetyltransferase:metabolism, Arylsulfotransferase:metabolism, Autoradiography, Catalysis, DNA:chemistry, DNA Adducts:chemistry, Deoxyguanosine:chemistry, Ellipticines:chemistry, Hydrogen-Ion Concentration, Indica.    Citation

OBJECTIVES: Ellipticine is a potent antineoplastic agent exhibiting multiple mechanisms of its action. Recently, we have found that 13-hyd.....

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Modulation of CYP1A1-mediated oxidation of carcinogenic azo dye Sudan I and its binding to DNA by cytochrome b5.

Stiborová M, Martínek V, Schmeiser H, Frei E.

Journal Article 2006; 27(Suppl 2): 35-39 PubMed PMID: 17159775  Keywords:  Animals, Coloring Agents:pharmacokinetics, Cytochrome P-450 CYP1A1:metabolism, Cytochromes b5:physiology, DNA:metabolism, DNA Adducts:metabolism, Humans, Male, Metabolic Detoxication, Phase I, Models, Biological, Naphthols:metabolism, Rabbits, Rats, Rats,.    Citation

OBJECTIVES: Modulation of the cytochrome P450 (CYP) 1A1-mediated oxidative activation and detoxication of carcinogenic Sudan I by the heme.....

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Cytochromes P450 reconstituted with NADPH: P450 reductase mimic the activating and detoxicating metabolism of the anticancer drug ellipticine in microsomes.

Kotrbová V, Aimová D, Brezinová A, Janouchová K, Poljaková J, Frei E, Stiborová M.

Evaluation Studies 2006; 27(Suppl 2): 18-22 PubMed PMID: 17159771  Keywords:  Animals, Antineoplastic Agents:pharmacokinetics, Cytochrome P-450 Enzyme System:chemistry, DNA Adducts:metabolism, Ellipticines:pharmacokinetics, Metabolic Detoxication, Phase I, Microsomes, Liver:chemistry, Models, Biological, NADP:chemistry, NADPH-Ferri.    Citation

OBJECTIVES: Ellipticine is a potent antineoplastic agent exhibiting multiple action mechanisms. Recently, we found that after cytochrome P.....

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Oxidative detoxication of carcinogenic 2-nitroanisole by human, rat and rabbit cytochrome P450.

Dracínska H, Miksanová M, Svobodová M, Smrcek S, Frei E, Schmeiser H, Stiborová M.

Journal Article 2006; 27(Suppl 2): 9-13 PubMed PMID: 17159769  Keywords:  Adolescent, Adult, Aged, Aniline Compounds:metabolism, Animals, Anisoles:pharmacokinetics, Carcinogens:pharmacokinetics, Child, Child, Preschool, Cytochrome P-450 Enzyme System:metabolism, Female, Humans, In Vitro Techniques, Male, Metabolic Detoxication,.    Citation

OBJECTIVES: The detoxifying metabolism of a potent rodent carcinogen, 2-nitroanisole (2-NA) by human, rabbit and rat cytochromes P450 (P45.....

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