Fungal neuroinfections: rare disease but unacceptably high mortality.

Njambi S, Huttova M, Kovac M, Freybergh P, Bauer F, Muli J.
  Vol. 28 (Suppl 2) 2007 Neuro endocrinology letters Journal Article   2007; 28(Suppl 2): 25-26 PubMed PMID:  17558372    Citation  Keywords:  Acquired Immunodeficiency Syndrome:complications, Antifungal Agents:therapeutic use, Brain Abscess:complications, Candidiasis:drug therapy, Child, Child, Preschool, Humans, Infant, Infant, Newborn, Meningitis, Cryptococcal:complications, Meningitis, Funga.   

: Within last 25 years we have observed 20 cases of fungal meningitis and/or cerebral abscesses. Commonest etiologic agens was Candida spp. (C. albicans 9 of 20). Molds were responsible for 4 cases of brain abscess. Mortality was 50% what seems to be very high. Extremely high mortality is caused by delayed onset of therapy, severe underlying disease and multiresistant fungal organisms such as Mucorales, Fusarium solani and Aureobasidium.