Articles by author - Petr Hodek

Quantification of interactions between cytochrome P450 2B4 and cytochrome b5 in a functional membrane complex.

Ječmen T, Ptáčková R, Kavan D, Cerná V, Hodek P, Stiborová M, Hudeček J, Sulc M.

Journal Article 2014; 35(Suppl 2): 114-122 PubMed PMID: 25638375  Keywords:  Animals, Aryl Hydrocarbon Hydroxylases:metabolism, Cell Membrane:metabolism, Cytochrome P450 Family 2, Cytochromes b5:metabolism,.    Citation

OBJECTIVES: The mammalian mixed function oxidase (MFO) system participates in hydroxylation of many hydrophobic endogenous compou.....

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Effect of chicken antibodies on inflammation in human lung epithelial cell lines.

Kubickova B, Majerova B, Hadrabova J, Noskova L, Stiborova M, Hodek P.

Journal Article 2014; 35(Suppl 2): 99-104 PubMed PMID: 25638373  Keywords:  Animals, Antibodies:immunology, Bacterial Infections:prevention & control, Cell Line, Chickens, Egg Yolk:immunology, Epithelial Cells:immunology, Humans, Immunoglobulin Fab Fragments:immunology, Immunoglobulins:immunology, Inflammation:immunology, Lung:im.    Citation

OBJECTIVES: As an alternative therapeutic approach for the prevention and treatment of bacterial infections with P. aeruginosa of.....

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Mapping of interaction between cytochrome P450 2B4 and cytochrome b5: the first evidence of two mutual orientations.

Sulc M, Jecmen T, Snajdrova R, Novak P, Martinek V, Hodek P, Stiborova M, Hudecek J.

Journal Article 2012; 33(Suppl 3): 41-47 PubMed PMID: 23353842  Keywords:  Animals, Aryl Hydrocarbon Hydroxylases:chemistry, Carbodiimides:chemistry, Chromatography, Liquid:methods, Cross-Linking Reagents:chemistry, Cytochrome P450 Family 2, Cytochromes b5:chemistry, Dimerization, Electrons, Mass Spectrometry:methods, Microsomes.    Citation

OBJECTIVES: The cytochrome P450 (P450) and cytochrome b5 are membrane hemoproteins composing together with flavoprotein NADPH:P450 reducta.....

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Role of cytochromes P450 in metabolism of carcinogenic aristolochic acid I: evidence of their contribution to aristolochic acid I detoxication and activation in rat liver.

Stiborova M, Mares J, Levova K, Pavlickova J, Barta F, Hodek P, Frei E, Schmeiser H.

Journal Article 2011; 32(Suppl 1): 121-130 PubMed PMID: 22167220  Keywords:  Animals, Aristolochic Acids:pharmacokinetics, Biotransformation, Carcinogens:pharmacokinetics, Cytochrome P-450 CYP1A1:genetics, Cytochrome P-450 CYP1A2, Cytochrome P-450 Enzyme System:genetics, Cytochromes:genetics, DNA Adducts:metabolism, Drug Evaluatio.    Citation

OBJECTIVE: The herbal drug aristolochic acid (AA) derived from Aristolochia species has been shown to be the cause of aristolochic acid ne.....

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Impact of beta-naphthoflavone on genotoxicity of food-derived carcinogens.

Hodek P, Krizkova J, Frei E, Singh R, Arlt V, Stiborova M.

Journal Article 2011; 32(Suppl 1): 25-34 PubMed PMID: 22167217  Keywords:  Animals, Carcinogens, Environmental:isolation & purification, Cytochrome P-450 CYP1A1:antagonists & inhibitors, DNA Damage:drug effects, Drug Evaluation, Preclinical, Enzyme Induction:drug effects, Enzyme Inhibitors:pharmacology, Food:toxicity, Food Conta.    Citation

OBJECTIVES: Benzo[a]pyrene (BaP) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) are carcinogens, which frequently occur in the.....

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Modulation of cytochrome P450 enzyme system by selected flavonoids.

Hodek P, Tepla M, Krizkova J, Sulc M, Stiborova M.

Journal Article 2009; 30(Suppl 1): 67-71 PubMed PMID: 20027147  Keywords:  Animals, Antioxidants:pharmacology, Benzoflavones:chemistry, Carbon Monoxide:metabolism, Cytochrome P-450 Enzyme System:metabolism, Cytochromes b5:metabolism, Cytochromes c:metabolism, Ferricyanides:metabolism, Flavonoids:chemistry, Fluorometry, Male, Mic.    Citation

OBJECTIVES: The aim of this study was to assess the effect of various flavonoids on the NADPH:cytochrome P450 oxidoreductase (CYPOR) activ.....

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