Articles by author - Romuald Hudecek

Human cytochromes P450 1A1 and 1A2 participate in detoxication of carcinogenic aristolochic acid.

Sistkova J, Hudecek J, Hodek P, Frei E, Schmeiser H, Stiborova M.

Journal Article 2008; 29(5): 733-737 PubMed PMID: 18987598  Keywords:  Animals, Aristolochic Acids:pharmacokinetics, Carcinogens:pharmacokinetics, Chromatography, High Pressure Liquid, Cytochrome P-450 CYP1A1:isolation & purification, Cytochrome P-450 CYP1A2:isolation & purification, Humans, Inactivation, Metabolic, Mice, Mi.    Citation

OBJECTIVES: A carcinogenic and nephrotoxic plant alkaloid, aristolochic acid (AA), causes the development of aristolochic acid nephropathy.....

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Induction of cytochromes P450 in small intestine by chemopreventive compounds.

Krizkova J, Burdova K, Hudecek J, Stiborova M, Hodek P.

Journal Article 2008; 29(5): 717-721 PubMed PMID: 18987596  Keywords:  Allyl Compounds:pharmacology, Animals, Anticarcinogenic Agents:pharmacology, Blotting, Western, Curcumin:pharmacology, Cytochrome P-450 CYP1A1:biosynthesis, Cytochrome P-450 CYP2B1:biosynthesis, Cytochrome P-450 Enzyme System:biosynthesis, Flavonoids:phar.    Citation

OBJECTIVES: Since flavonoids and other natural compounds exert beneficial effects on human health, their consumption rapidly increases. Ho.....

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Isolation and partial characterization of the adduct formed by 13-hydroxyellipticine with deoxyguanosine in DNA.

Moserova M, Kotrbova V, Rupertova M, Naiman K, Hudecek J, Hodek P, Frei E, Stiborova M.

Journal Article 2008; 29(5): 728-732 PubMed PMID: 18987592  Keywords:  Acetyl Coenzyme A:metabolism, Arylamine N-Acetyltransferase:metabolism, Arylsulfotransferase:metabolism, Autoradiography, Catalysis, DNA:chemistry, DNA Adducts:chemistry, Deoxyguanosine:chemistry, Ellipticines:chemistry, Hydrogen-Ion Concentration, Indica.    Citation

OBJECTIVES: Ellipticine is a potent antineoplastic agent exhibiting multiple mechanisms of its action. Recently, we have found that 13-hyd.....

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Structural analysis of binding of a diamantoid substrate to cytochrome P450 2B4: possible role of Arg 133 in modulation of function and activity of this enzyme.

Sulc M, Hudecek J, Stiborova M, Hodek P.

Journal Article 2008; 29(5): 722-727 PubMed PMID: 18987581  Keywords:  Adamantane:analogs & derivatives, Amino Acid Sequence, Animals, Arginine:genetics, Aryl Hydrocarbon Hydroxylases:antagonists & inhibitors, Chromatography, High Pressure Liquid, Crystallography, X-Ray, Cytochrome P450 Family 2, Enzyme Inhibitors:pharmacolo.    Citation

OBJECTIVES: Understanding the enzyme mechanism of P450 enzymes needs a detailed knowledge of substrate-enzyme interactions. Here, we exami.....

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Diagnosis and treatment of metal-induced side-effects.

Stejskal V, Hudecek R, Stejskal J, Sterzl I.

Journal Article 2006; 27(Suppl 1): 7-16 PubMed PMID: 17261999  Keywords:  Biomarkers:blood, Dental Amalgam:toxicity, Environmental Pollutants:toxicity, Humans, Hypersensitivity:diagnosis, Inflammation, Lymphocyte Activation, Metals:toxicity, T-Lymphocytes:immunology, Titanium:toxicity,.    Citation

: Environmental factors are recognized as a cause of the increasing frequency of allergic and autoimmune diseases. In addition to external.....

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Metal-specific lymphocyte reactivity is downregulated after dental metal replacement.

Yaqob A, Danersund A, Stejskal V, Lindvall A, Hudecek R, Lindh U.

Journal Article 2006; 27(1-2): 189-197 PubMed PMID: 16648791  Keywords:  Adolescent, Adult, Aged, Antioxidants:therapeutic use, Biocompatible Materials:adverse effects, Cell Separation, Chronic Disease, Dental Materials:metabolism, Down-Regulation, Enzyme-Linked Immunosorbent Assay, Fatigue Syndrome, Chronic:etiology, Female, .    Citation

OBJECTIVES: This study was done to evaluate the results and clinical relevance of an optimized lymphocyte proliferation test, MELISA, for .....

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