Is combination therapy with betalactam plus aminoglycoside (AGL) improving the outcome of nosocomial meningitis in children?

Ondrusova A, Grey E, Benca J, Rudinsky B, Huttova M, Bauer F, Kovac M, Sramka M.
  Vol. 28 (Suppl 2) 2007 Neuro endocrinology letters Comparative Study   2007; 28(Suppl 2): 17-18 PubMed PMID:  17558368    Citation  Keywords:  Aminoglycosides:administration & dosage, Anti-Bacterial Agents:administration & dosage, Carbapenems:administration & dosage, Child, Child, Preschool, Cross Infection:drug therapy, Drug Therapy, Combination, Glycopeptides:administration & dosage, Humans, I.   

: We have been unable to document a benefit of a combination of aminoglycosides with betalactam or carbapenem antibiotics in nosocomial meningitis. This was similar to the cases of sepsis, where survival of patients did not improve with combination therapy. Combination therapy did not increase the chance of appropriateness of the therapy. 30% of those on combination therapy were considered as inappropriately treated in comparison to 2.8% of those on monotherapy (p<0.01).