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Journal Article 2012; 33(6): 636-642 PubMed PMID: 23160222 Citation  Keywords:  Adaptation, Psychological:physiology, Adolescent, Biological Evolution, Dominance-Subordination, Female, Hierarchy, Social, Humans, Male, Masochism:physiopathology, Sadism:physiopathology, Sexual Behavior:physiology, Social Behavior, Surveys and Questionn.   

OBJECTIVES: We theorize that sexual arousal by dominance and submission may be connected to a reproduction strategy respecting a reached social dominance rank (a common reproduction strategy in socially living mammals), while the preference for "bondage" may be derived from an opportunistic strategy when being unable to compete for hierarchic rank (an alternative reproductive strategy that co-occurs frequently with the above-named main strategy). The answers to questions dealing with hierarchy in character should correlate exclusively with sexual arousal connected to any kind of expression of a hierarchy, but not with bondage.

DESIGN AND SETTINGS: The data were obtained from young adults (157 males and 183 females aged 18-20, with mean 18.4 years) via questionnaires.

RESULTS: Seven out of eight questions dealing with hierarchy correlated with sexual arousal by dominance and submission in men (Spearman's r=0.169-0.313; p<0.05 - p<0.001), two questions correlated with sexual arousal by dominance and submission in women (Spearman's r=0.32-0.166, p<0.001, p<0.05). THE MAIN FINDINGS: The questions dealing with hierarchy correlated with sexual arousal by dominance and submission while no answers correlated with bondage, neither in men nor in women.

CONCLUSION: The preference for sexual arousal by dominance and submission may be connected to strategy respecting rank, while the preference for "bondage" may be derived from an opportunistic strategy that may be essential for possible partner problems solution. From the evolutionary biology point of view, these patterns of sadomasochistic sex appear as adaptive rather than as pathology....

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Journal Article 2012; 33(4): 462-468 PubMed PMID: 22936254 Citation  Keywords:  Adaptation, Physiological, Automobile Driving, Biomechanical Phenomena, Case-Control Studies, Female, Humans, Pregnancy:physiology, Reference Values, Spine:physiology, Stress, Physiological:physiology, Vibration, Weight-Bearing:physiology,.   

OBJECTIVES: During a longer car drive there are changes in rheological properties of driver's or passenger's connective tissues taking place as a consequence of monotonous and vibration load. These changes show more among the pregnant drivers, whose motion system is under heavier demands due to pregnancy. To asses these changes we have used the TVS (transfer vibration through the spine) method.

METHODS: The TVS is based on application of γ excitation pulses with half-length 5 ms and then harmonic excitation continuously periodically changing from 5 Hz to 160 Hz on C7 and L5 vertebrae. This wave is transferred along the axial system and the acceleration of all the spinous tips of the vertebrae, along which the waves spread between C7 and S1, is detected by accelerometric sensors. The measurement was carried out on three drivers before and after a 4-hours driving. The same measurements of wave transfer along the spine with just one pregnant woman were carried out in th 16th, 26th and 32nd week of pregnancy. Consequently we constructed a simplified model of the spine in order to analyze gathered data by discovering elementary properties of the measured system.

RESULTS: After both vibration and physical load there is a more significant dampening of the spinal tissues apparent, i.e. lower acceleration amplitude and the tissues resonance frequency also shifts towards the lower frequencies. On the other hand after long lasting relaxation on a bed an opposite tendency showed, the acceleration amplitude was higher, tissues were relaxed and dampening was lower. The same tendency manifested among the pregnant women. The influence of progressing pregnancy on the spinal segment transfer function showed through a shifting of peaks above 20Hz. Their size also changes monotonously. An absorption area moves towards higher frequencies, rigidity of axial system connections grows.

CONCLUSION: The results say that drivers, including pregnant women, show changes in mechanical properties of examined tissues before and after vibration or other type of load. Or conversely before and after relaxation on a bed. Results of this work will be further analyzed, verified and evaluation procedures will be improved. We expect to find dependencies between excitation and resonance frequencies during the transfer via the axial system, the rheological properties of the axial system components and the physical nature of the load of the axial system. They are then going to be applicable for the prevention of injuries of the axial system, physiotherapy practices in the rehabilitation of post-operative conditions, the dosage of training loads of athletes, in determining the effects of job stress regimes and their prevention....

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Comparative Study 2011; 32(5): 691-696 PubMed PMID: 22167130 Citation  Keywords:  Adaptation, Physiological:physiology, Adolescent, Anorexia Nervosa:metabolism, Body Mass Index, Child, Female, Humans, Obesity:metabolism, ROC Curve, Resistin:blood, Young Adult,.   

OBJECTIVES: There are only few studies available on blood resistin (RES) levels in patients with anorexia nervosa (AN), which revealed scarce results, however it has been demonstrated that RES mRNA expression in adipose tissue of these patients is increased. The aim of this study is: 1) the evaluation of serum resistin levels in girls with AN and determination a threshold value differentiating these patients from healthy subjects; 2) analysis of the relationship between serum resistin levels and BMI in examined subjects.

DESIGN AND SETTING: Serum RES concentration has been assayed using ELISA kit in 195 adolescent girls: 87 with restrictive AN (mean BMI-SDS: -2.65 ± 0.2), 17 with not otherwise specified eating disorders (NOS) (mean BMI-SDS: -1.4 ± 0.68), 30 with simple obesity (OB) (mean BMI-SDS: 6.91 ± 1.23) and 61 healthy (mean BMI-SDS: -0.18 ± 0.54).

RESULTS: Mean serum RES concentration in AN (2.8 ± 0.6 ng/ml) and NOS (3.1 ± 0.9 ng/ml) were significantly lower (p<0.0001) than in OB and H groups (4.8 ± 0.5 and 4.1 ± 0.4 ng/ml respectively). After corrected for BMI, RES values in AN were similar as in H subjects, but significantly higher (p<0.005) in comparison to OB group. ROC curve analysis revealed that 3.87 ng/ml is the threshold value of RES serum concentration differentiating AN from H girls (specificity 100%, sensitivity 80%). No significant correlations between BMI and serum resistin concentration are found in AN group, although a significant positive correlation has been established for all examined subjects.

CONCLUSION: Additional adaptive mechanisms may be involved in regulation of RES levels in adolescent girls with AN....

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Journal Article 2011; 32(2): 111-120 PubMed PMID: 21552202 Citation  Keywords:  Adaptation, Psychological:physiology, Emotions:physiology, Humans, Integrative Medicine:methods, Interpersonal Relations, Mental Health, Neurosciences:methods, Object Attachment, Personality Development,.   

: Attachment theory is a very influential general concept of human social and emotional development, which emphasizes the role of early mother-infant interactions for infant's adaptive behavioural and stress copying strategies, personality organization and mental health. Individuals with disrupted development of secure attachment to mother/primary caregiver are at higher risk of developing mental disorders. This theory consists of the complex developmental psycho-neurobiological model of attachment and emerges from principles of psychoanalysis, evolutionary biology, cognitive-developmental psychology, ethology, physiology and control systems theory. The progress of modern neuroscience enables interpretation of neurobiological aspects of the theory as multi-level neural interactions and functional development of important neural structures, effects of neuromediattors, hormones and essential neurobiological processes including emotional, cognitive, social interactions and the special key role of mentalizing. It has multiple neurobiological, neuroendocrine, neurophysiological, ethological, genetic, developmental, psychological, psychotherapeutic and neuropsychiatric consequences and is a prototype of complex neuroscientific concept as interpretation of modern integrated neuroscience....

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Clinical Trial 2010; 31(5): 663-666 PubMed PMID: 21178946 Citation  Keywords:  5-Hydroxytryptophan:administration & dosage, Adaptation, Psychological:drug effects, Adult, Antidepressive Agents, Second-Generation:administration & dosage, Austria, Blood Platelets:chemistry, Brain-Derived Neurotrophic Factor:blood, Courtship:psychology.   

: This open-label trial assessed the clinical efficacy of L-5-hydroxytryptophan (5-HTP), a natural serotonin precursor, in nondepressed young subjects with high levels of romantic stress. Since both neurotrophins and serotonin have been linked to human romantic attachment, we sought to investigate the changes in serum brain-derived neurotrophic factor (BDNF) levels and platelet serotonin content in relation to the changes in romantic stress throughout the study. A total of 15 healthy subjects (11 females and 4 males, mean age: 23.3 ± 2.1 years) who experienced a recent romantic break-up or reported recent romantic problems took part in the study. The participants were treated openly for 6 weeks with L-5-hydroxytryptophan (60 mg Griffonia simplicifolia extract containing 12.8 mg 5-HTP b.i.d., Amorex, Coropharm, Villach, Austria). The subjects were evaluated at baseline, at 3 weeks and at the end of the 6-week trial using an adapted version of the Seiffge-Krenke's Problem Questionnaire. BDNF and platelet serotonin content were determined at baseline, at 3 weeks, and after the completion of the 6-week trial. We observed significant improvements in romantic stress scores from weeks 0 through 3 (p=0.007) but no further significant improvement was evident from weeks 3 through 6 (p=0.19). At 6 weeks, subjects had a significant increase from baseline in both BDNF and platelet serotonin values. Our data suggest that direct modulation of the serotonergic system may have use for the treatment of psychological suffering associated with unreciprocated romantic love....

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Journal Article 2008; 29(6): 1015-120 PubMed PMID: 19112418 Citation  Keywords:  Adaptation, Physiological, Adrenal Medulla:enzymology, Analysis of Variance, Animals, Catecholamines:biosynthesis, Dopamine beta-Hydroxylase:genetics, Gene Expression Regulation:physiology, Immobilization, Male, Phenylethanolamine N-Methyltransferase:gene.   

OBJECTIVE: Isolation of adult animals represents a form of psychsocial stress that produces sympatho-adrenomedullar activation. The aim of this work was to investigate the changes in gene expression and protein levels of catecholamine biosynthetic enzymes: tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) in the adrenal medulla of naive control and chronically (12 weeks) socially isolated adult Wistar rat males and the response of these animals to additional immobilization stress (2 h).

METHODS: TH, DBH and PNMT mRNA levels were quantified by quantitative real-time RT-PCR (qRT-PCR). TH, DBH and PNMT immunoproteins were assayed by Western Blot.

RESULTS: In chronically isolated rats, gene expression levels of catecholamine biosynthetic enzymes in the adrenal medulla were decreased, but only TH mRNA was significantly decreased. However, protein levels of TH, DBH and PNMT of these animals were elevated by 55%, 20% and 18%, respectively, in relation to the corresponding control. Naive control and chronically socially isolated rats exposed to additional 2-h-immobilization showed increased gene expression of the examined enzymes, the increase being greater in socially isolated rats as compared to the controls. Additional immobilization of naive controls did not affect TH, DBH and PNMT protein levels. In contrast, this stress produced increased TH, DBH and PNMT protein levels in long-term socially isolated rats.

CONCLUSION: We can conclude that psychosocial stress expressed a differential influence on gene expression and protein levels of catecholamine biosynthetic enzymes in the adrenal medulla of adult rats. The results indicate a possible adaptation of catecholamine-synthesizing system at the level of TH gene expression in adrenal medulla of chronically isolated animals....

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Journal Article 2007; 28(6): 822-825 PubMed PMID: 18063938 Citation  Keywords:  Adaptation, Physiological, Age Factors, Analysis of Variance, Blood Flow Velocity:physiology, Female, Hemodynamics, Humans, Infant, Newborn, Intestines:blood supply, Male, Mesenteric Artery, Superior:diagnostic imaging, Reference Values, Regional Blood Fl.   

OBJECTIVES: After birth, the newborn intestinal circulation undergoes physiological changes. The purpose of this work was to characterize the changes in mesenteric blood flow velocity occuring during the first three days of life in healthy term infants.

METHODS: 30 healthy term newborns were studied repeatedly at the age of 2, 24 and 70 hours. Blood flow velocity in superior mesenteric artery (SMA) was measured by Doppler ultrasound, peak systolic velocity (PSV), end-diastolic velocity (EDV) and time-averaged mean velocity (TAV) were recorded at each time point. Resistance index (RI) and pulsatility index (PI) were calculated.

RESULTS: SMA EDV increased from 2 h [-5.2+/-6.8 cm/s (mean +/- SD)] to 24 h (12.9+/-3.8 cm/s, p<0.001) with further insignificant increase to 70 h (14.9+/-4.7 cm/s). At 2 h of age the mean EDV was negative in 23 of 30 cases (76.7%). PSV did not change between 2 h (58.0+/-21.8 cm/s) and 24 h (58.5+/-15.0 cm/s) but it increased to 70 h (79.6+/-17.7 cm/s). TAV showed a significant increase with time. RI decreased from 2 h (1.09+/-0.11) to 24 h (0.78+/-0.06, p<0.001) with further insignificant increase to 70 h (0.81+/-0.06).

CONCLUSIONS: The blood flow velocity in SMA increases during the early neonatal period in term infants. The most remarkable changes occur within the first 24 hours of life. At 2 h of age a reversed blood flow is present in majority of infants....

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Journal Article 2007; 28(5): 647-651 PubMed PMID: 17984951 Citation  Keywords:  Adaptation, Physiological, Adult, Aged, Brain:blood supply, Carotid Artery Diseases:classification, Carotid Artery, Internal:abnormalities, Cerebrovascular Circulation:physiology, Child, Female, Humans, Intracranial Aneurysm:etiology, Male, Mass Screening.   

BACKGROUND: Agenesis of one or both internal carotid arteries (ICA) is usually a benign congenital anomaly. Many patients are diagnosed incidentally and remain asymptomatic, however associated cerebral aneurysms can be life-threatening and result in high morbidity and mortality rates in this population.

MATERIAL & METHODS: Based on the timing of ICA agenesis, during the fetal life, we classified the collateral blood flow pattern into three major types; type I: Collateral blood flow via primitive vessels, type II: Collateral blood flow via ICA branches, and type III: collateral blood flow via branches of the external carotid artery (ECA). The type of collateral blood flow pattern in the reported patients with ICA agenesis and cerebral aneurysm was reviewed in order to determine the relation between the type of collateral blood flow and the development of CAs.

RESULTS: Twenty nine patients with ICA agenesis and CA were reported, of these 27 patients (93%) were found to have type II collateral blood flow, 2 patients (7%) had type I collateral blood flow pattern and none had type III collateral flow pattern. The majority of patients (79%) with CA secondary to ICA agenesis presented with subarachinoid hemorrhage (SAH).

CONCLUSION: Although ICA agenesis is a symptomatic in the majority of cases, it must be recognized because it promotes the development of CA and SAH. Our new classification system for collateral blood flow patterns is easy to use and can predict those at high risk to develop cerebral aneurysms and SAH, and therefore, need annual screening MRA....

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