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Journal Article 2007; 28(Suppl 2): 30-31 PubMed PMID: 17558374 Citation  Keywords:  Anti-Bacterial Agents:therapeutic use, Cross Infection:drug therapy, Humans, Hydrocephalus:etiology, Infant, Newborn, Language Development Disorders:etiology, Meningitis, Bacterial:drug therapy, Rare Diseases, Retrospective Studies, Streptococcal Infectio.   

: Streptococcus agalactiae is a rare cause of neonatal meningitis in the era of peripartum prophylaxis with prophylaxis with ampicillin in colonized/infected mothers. However 5 cases of meningitis among 171 cases of pediatric nosocomial meningitis database within last 15 years occurred. All 5 children were neonates (one VLBW and early gestation newborn), 2 after neurosurgery. All 5 cases were successfully cured with a combination of cefotaxim (or ceftazidim) plus aminoglycosides, in one case also with addition of vancomycin or ampicillin. However 3 of 5 cured patients had neurologic sequellae, two of them reversible hydrocephalus and in speech retardation....

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Journal Article 2007; 28(Suppl 2): 27-29 PubMed PMID: 17558373 Citation  Keywords:  Anti-Bacterial Agents:therapeutic use, Child, Child, Preschool, Cross Infection:drug therapy, Drug Resistance, Bacterial, Enterobacteriaceae Infections:complications, Female, Humans, Infant, Infant, Newborn, Male, Meningitis, Bacterial:drug therapy, Risk .   

: Nosocomial neuroinfections due to Enterobacteriaceae represented 9.5% in our cohort of 171 cases of paediatric meningitis within last 15 years. Commonest etiologic agents was E. coli - 9 (50%) followed by Klebsiella pneumoniae - 3 (16,7%) and Enterobacter cloacae. Citrobacter freundii, Proteus mirabilis and Salmonella enteritidis (1 each). Commonest risk factors were neonatal age 13 - (72.2%), very low birth weight 5 (27.8%), craniocerebral trauma - 4 (22.2%) and neurosurgery - 5 (27.8%). All but 1 case were treated with antibiotics: 8 with III-rd and 3 with IV-th generation cephalosporins (ceftazidim, cefotaxim and cefepim) 2 with meropenem and 4 with ciprofloxacin: Nosocomial meningitis due to enterobacteriaceae was associated with significantly high mortality (29.9% vs. 15.1% in all cohort of pediatric meningitis - p<0.02)....

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Journal Article 2007; 28(Suppl 2): 20-21 PubMed PMID: 17558370 Citation  Keywords:  Adolescent, Anti-Bacterial Agents:therapeutic use, Cefotaxime:therapeutic use, Ceftazidime:therapeutic use, Chi-Square Distribution, Child, Preschool, Chloramphenicol:therapeutic use, Cross Infection:drug therapy, Drug Therapy, Combination, Female, Gentam.   

: Risk factors, therapy and outcome of 15 cases of nosocomial meningitis due to Pseudomonas aeruginosa is reviewed. No difference in risk factors was found, however mortality for Ps. aeruginosa was significantly higher (33.3 vs 15.1% p<0.04)....

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Letter 2007; 28(Suppl 2): 20-21 PubMed PMID: 17558369 Citation  Keywords:  Aminoglycosides:therapeutic use, Anti-Bacterial Agents:therapeutic use, Carbapenems:therapeutic use, Child, Child, Preschool, Cross Infection:drug therapy, Drug Therapy, Combination, Humans, Infant, Infant, Newborn, Meningitis, Bacterial:drug therapy, Ret.   

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Comparative Study 2007; 28(Suppl 2): 17-18 PubMed PMID: 17558368 Citation  Keywords:  Aminoglycosides:administration & dosage, Anti-Bacterial Agents:administration & dosage, Carbapenems:administration & dosage, Child, Child, Preschool, Cross Infection:drug therapy, Drug Therapy, Combination, Glycopeptides:administration & dosage, Humans, I.   

: We have been unable to document a benefit of a combination of aminoglycosides with betalactam or carbapenem antibiotics in nosocomial meningitis. This was similar to the cases of sepsis, where survival of patients did not improve with combination therapy. Combination therapy did not increase the chance of appropriateness of the therapy. 30% of those on combination therapy were considered as inappropriately treated in comparison to 2.8% of those on monotherapy (p<0.01)....

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Journal Article 2007; 28(Suppl 2): 15-16 PubMed PMID: 17558367 Citation  Keywords:  Acinetobacter Infections:drug therapy, Acinetobacter baumannii:immunology, Anti-Bacterial Agents:therapeutic use, Central Nervous System:abnormalities, Child, Child, Preschool, Cross Infection:drug therapy, Humans, Infant, Newborn, Infant, Very Low Birth .   

: Twenty five (25) cases of nosocomial postsurgical meningitis due to Acinetobacter baumannii meningitis were compared to other 146 cases of meningitis after surgery caused by other pathogens. Prior neurosurgical ventriculo-peritoneal shunt insertion and CNS abnormality as well as very low birth weight were significant risk factors for acquisition of Acinetobacter baumannii meningitis. Mortality - 40% among children with nosocomial meningitis was unacceptably high and significantly higher than among meningitis caused by microorganisms other than Acinetobacter baumannii....

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Clinical Trial 2004; 25(5): 373-380 PubMed PMID: 15580173 Citation  Keywords:  Adolescent, Adult, Anti-Bacterial Agents:therapeutic use, Combined Modality Therapy, Female, Gestational Age, Humans, Obstetric Labor, Premature:therapy, Pregnancy, Pregnancy Outcome, Tocolysis, Treatment Outcome,.   

OBJECTIVE: The aim of this study was to determine: a) to what extent application of antibiotics enhances efficiency of tocolysis; b) whether the duration of antibiotic treatment influences its efficacy; c) what criterion is decisive for efficacy of tocolysis assisted by antibiotic therapy.

MATERIALS AND METHODS: 223 successive women with unifetal pregnancies, aged 17 to 42 (average age 27.3), admitted to the Department of Gynecology and Obstetrics of the JU Medical College in the period from January 1, 1999 to September 9, 2001, were enrolled in the study. Using clinical methods such as: assessment of contractile activity of the uterus, of uterine cervix and membranes, presence of bleeding and other clinical symptoms, these women were diagnosed with imminent preterm labour.

CONCLUSIONS: Antibiotic treatment enhances the efficacy of tocolysis, influencing the time of prolonging pregnancy in imminent preterm delivery. This synergistic effect is clinically crucial as in this way significantly larger number of children will be born at term and also a number of premature neonates who survive may be increased....

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Journal Article 2003; 24(5): 350-354 PubMed PMID: 14647012 Citation  Keywords:  Animals, Anti-Bacterial Agents:pharmacology, Antioxidants:pharmacology, Female, Graft Survival, Malondialdehyde:blood, Melatonin:pharmacology, Necrosis, Ovary:metabolism, Oxytetracycline:pharmacology, Peritoneal Cavity, Rats, Rats, Wistar,.   

OBJECTIVES: To comparatively investigate the effects melatonin and oxytetracycline as antioxidants on autologous intraperitoneal ovary transplantation in rats.

SETTING AND DESIGN: 28 adult female Wistar rats with regular estrous cycles were randomly divided into four groups. Group 1 (n=7) was the control group; Group 2 (n=7) bilateral oophorectomy and intraperitoneal transplantation group; and Groups 3 (n=7) and 4 (n=7) firstly received 20 mg/kg/IP melatonin and 10 mg/kg/IP oxytetracycline., respectively and fifteen minutes after that, they had bilateral oophorectomy and intraperitoneal transplantation. Ovarian tissue and blood malondialdehyde (MDA) levels, superoxide dismutase (SOD) and glutathione peroxidase (GSHPx) levels were determined. Vaginal cytology and ovarian necrosis were histopathologically investigated. Kruskall Wallis analysis of variance was used in the statistical analysis of data.

RESULTS: Ovarian necrosis, tissue MDA and plasma MDA levels were significantly higher in Group 2 compared to the Groups 1, 3 and 4 (p<0.03). SOD and GSHPx levels were significantly lower in group 2 compared to the groups 1, 3 and 4 (p<0.03). Melatonin was found to be more effective on ovarian necrosis and tissue MDA level than the use of oxytetracycline following autologous intraperitoneal ovary transplantation (p<0.03). There was a significant positive correlation between tissue MDA level and ovarian necrosis and a very strong negative correlation between tissue MDA and SOD level (rs = +/-0.9, n=28, p=0.000).

CONCLUSION: Although both melatonin and oxytetracycline were found to be effective in autologous intraperitoneal pelvic ovary transplantation, melatonin is more effective against both the ovarian necrosis and tissue MDA level in rats....

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