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Comment 2011; 32(4): 369-370 PubMed PMID: 21876514 Citation  Keywords:  Aspirin:pharmacology, Female, Humans, Platelet Aggregation Inhibitors:pharmacology, Pregnancy, Pregnancy Outcome,.   

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Journal Article 2011; 32(3): 334-339 PubMed PMID: 21670728 Citation  Keywords:  Adult, Aspirin:pharmacology, Cesarean Section, Drug Resistance, Female, Fetal Distress:epidemiology, Humans, Infant, Newborn, Infant, Small for Gestational Age, Lupus Erythematosus, Systemic:blood, Obstetric Labor, Premature:epidemiology, Parity, Platelet.   

OBJECTIVE: Verify that resistance to aspirin may have an impact on pregnancy and neonatal outcome.

METHODS: We enrolled 43 pregnant women, aged 30.7 ± 4.0 years regularly taking 75 mg of aspirin daily and 32 (aged 30.8 ± 4 years) pregnant women not receiving aspirin who served as control group. Laboratory tests were performed at 18 to 22 weeks of gestation, 28 to 32 weeks of gestation and 16 to 32 weeks after delivery. Resistance to aspirin was defined as urinary 11-dehydrothromboxane B2 (u11-dTXB2) concentrations in the highest quartile and additionally, as the resistance index (RI) calculated for each woman, defined as the difference between u11-dTXB2 concentration of each woman treated with aspirin and the median value at the same time point measured in the control group.

RESULTS: Women taking aspirin in the highest quartile of u11-dTXB2 delivered prematurely (35.8±3.4 vs 38.1±1.7 weeks, p=0.02). Delivery of small for gestational age (SGA) newborns (p=0.003) as well as fetal distress (p=0.014) and preeclampsia (p=0.003) occured more frequently in aspirin-resistant women. Resistance to aspirin based on the RI value was also associated with higher prevalence of preeclampsia (p=0.02) and SGA newborns delivery (p=0.01). The two groups resistant to ASA designed on the basis of both (RI and u11-dTXB2 urine levels) methods compared with ASA sensitive group differed in frequency of SLE prevalence.

CONCLUSION: Aspirin resistance may be associated with increased risk of adverse pregnancy outcomes including preeclampsia, premature delivery and delivery of SGA newborns....

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Journal Article 2003; 24(5): 304-309 PubMed PMID: 14647001 Citation  Keywords:  Analgesics:pharmacology, Analgesics, Opioid:pharmacology, Animals, Antioxidants:pharmacology, Ascorbic Acid:pharmacology, Aspirin:pharmacology, Drug Therapy, Combination, Free Radicals:metabolism, Lipid Peroxidation:drug effects, Male, Morphine:pharmacolo.   

OBJECTIVES: To study the balance between the pro-oxidative and antioxidative defence system after repeated painful stimulation in rats and the efficacy of the administration of different antioxidants (vitamins C, E, A, and selenium), analgesics (acetylsalicylic acid, morphine), and their combinations.

METHODS: Mechanical clamping of both hind limbs was applied for 10 min for 5 consecutive days in adult male Wistar rats. The tail-flick latency was measured before and after a 5-day nociceptive stimulation with or without the substance application. The reactive oxygen species (ROS) were determined in the sensorimotor cortex.

RESULTS: Painful stimulation increased lipoperoxidation which persisted for up to 15 days after it had been discontinued. A simultaneous injection of antioxidants decreased the levels of TBARS, SOD and GSHPx; however, antioxidants applied one week prior to the painful stimulation were ineffective. A simultaneous injection of analgesics reduced stress-induced analgesia caused by the nociceptive stimulation, but did not affect lipoperoxidation.

CONCLUSIONS: A combination of antioxidants with analgesics normalized both the oxidative stress and functional (the tail-flick latency) indicators. These results suggest that the administration of antioxidants in pain treatment may be employed to decrease the doses of analgesics and to prevent the negative impact of reactive oxygen species on nociception....

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