Chronomics complement, among many other fields, genomics and proteomics.
...
Citation
Chronomics complement, among many other fields, genomics and proteomics. Neuro Endocrinol Lett. 2001 Jan; 22(1): 53-73
...
Chronomics complement, among many other fields, genomics and proteomics. Neuro Endocrinol Lett. 2001 Jan; 22(1): 53-73
OBJECTIVE: To evaluate the association of heart rate variability (HRV) examined in supine and standing position with ambulatory blood pressure monitoring (ABPM) in patients with anorexia nervosa (AN).
METHODS: HRV in supine and standing position and ABPM were examined in 30 AN patients and 30 control subjects. The correlations between HRV and ABPM were evaluated.
RESULTS: The average age was 25±5 in AN patients and 25±4 years in controls (NS). LF (low frequency) power in AN patients and controls was comparable in supine position. LF power significantly increased during standing in controls, but no increment was detected in AN patients. The HF (high frequency) power was significantly increased in AN patients in supine position, but after standing was comparable with controls. The ratio LF/HF was lower both in supine and standing position in AN patients but the differences did not reach statistical significance. Blood pressure values in AN patients were comparable with controls in supine position but were significantly lower in standing position. Ambulatory blood pressure values were significantly lower in AN patients during active but not sleeping period. In standing position HF and LF powers positively and LF/HF negatively correlated with ABPM blood pressure values during active period in controls while in AN patients only LF power correlated with diastolic and mean blood pressures.
CONCLUSION: The lower ABPM values in AN patients during active period in comparison with control subjects may be explained by HRV changes, mainly by its impaired relations with blood pressure in standing position....
Palova S, Havlin J, Charvat J. The association of heart rate variability examined in supine and standing position with ambulatory blood pressure monitoring in anorexia nervosa. Neuro Endocrinol Lett. 2012 Jan; 33(2): 196-200
OBJECTIVE: The aim of the study was to establish the concentration of blood pressure regulating hormones in premenopausal women with isolated systolic hypertension (ISH) related to hyperthyroidism (HT).
MATERIAL AND METHODS: 61 females with HT were enrolled in the study, including 28 with ISH (Group A), 33 with normal arterial blood pressure (Group B) and 34 healthy individuals (Group C). It was determined - plasma renin activity (PRA), plasma concentration of arginine vasopressin (AVP), atrial natriuretic hormone (ANH) and aldosterone (Aldo). PRA and Aldo tests were performed twice, firstly under basal conditions and then after a 3-day low-sodium diet. In hyperthyroid patients tests were repeated during thyreostatic treatment. Patients with sodium-sensitivity of blood pressure were selected. Cardiac index (CI) and total peripheral resistance index (TPRI) were calculated.
RESULTS: In ISH patients the basal PRA was lower than in patients of Groups B and C. The highest poststimulatory PRA was observed in patients of Group B. ANH concentration was higher in both HT groups compared to the Group C. AVP concentration in ISH patients was higher than in Group C. In HT patients blood pressure correlated with basal PRA, CI and TPRI. Sodium sensitivity of blood pressure was observed more frequently in patients from Group A.
CONCLUSIONS: In women, ISH in HT is the consequence of the increased cardiac output and the decreased peripheral vascular resistance. ISH related to HT results in the reduction in basal PRA probably as the result of intensified cardiac ejection function. ISH in hyperthyroid patients shows a higher sodium-sensitivity....
Marcisz C, Nowakowski G, Marcisz-Orzel M, Sioma-Markowska U, Gladysz R, Zajdel-Stachon M. The concentration of blood pressure regulating hormones in premenopausal women with isolated systolic hypertension related to hyperthyroidism. Neuro Endocrinol Lett. 2012 Jan; 33(1): 81-89
OBJECTIVES: Vascular erectile dysfunction (ED) predicts future development of cardiovascular diseases (CVD). We performed a study in men seeking consultant medical advice regarding vascular ED for the first time without a history of cardiovascular disease, diabetes mellitus or renal insufficiency. Our goal was to evaluate the prevalence of CVD risk factors in this cohort of patients. Furthermore, we assessed the prevalence of asymptomatic subclinical atherosclerosis.
MATERIAL AND METHODS: All study subjects underwent a thorough physical examination including anthropometric measurements. Laboratory analyses comprising assessment of lipid spectrum, liver and kidney function tests, glycaemia and glycated haemoglobin were measured using automated analysers. Intima-media thickness of carotid arteries was measured using SONOS machine and ankle-brachial index using a mini-duplex device. CVD risk was calculated by standard SCORE charts. Chi-square test, t-test and ANOVA were used for statistical analysis.
RESULTS: We examined 35 men, average age 46.5 ± 9.9 years. Six (17.1%) had a positive family history of CVD, 19 (54.3%) had dyslipidemia, 10 (28.6%) were obese, 9 (25.7%) were active smokers, and 14 (40.0%) had arterial hypertension. Eighteen (51.4%) subjects had subclinical atherosclerosis as determined by ABI and CIMT assessment.
CONCLUSION: Patients with vascular erectile dysfunction have similar prevalence of CVD risk factors to general population....
Prusikova M, Vrablik M, Zamecnik L, Horova E, Lanska V, Ceska R. Prevalence of risk factors of cardiovascular diseases in men with erectile dysfunction. Are they as frequent as we believe? Neuro Endocrinol Lett. 2011 Jan; 32(Suppl 2): 60-63
OBJECTIVES: Omega-3 fatty acids (FA) have been shown to be protective against cardiovascular diseases (CVD). The effect of the consumption of carp meat on CVD risk factors has not yet been examined in detail. We ascertained the influence of a diet enriched with carp meat with an elevated content of omega-3FA (200 g twice weekly for 4 weeks) in a group of subjects after cardiac revascularization surgery for ischemic heart disease with a follow-up spa treatment.
DESIGN: After cardiac revascularization surgery, the probands consumed either a standard spa diet (56 individuals, 41 males, 15 females, age 41-80 years) or a diet enriched with two portions of carp meat (87 individuals, 64 males, 23 females, age 50-82 years). The differences in body mass index (kg/m²), blood pressure, plasma lipids and C-reactive protein (CRP) of the groups were analyzed.
RESULTS: In the group with a higher consumption of carp meat, significantly greater improvements in lipid parameters in comparison to the standard spa diet were detected (total cholesterol p<0.001, triglycerides p<0.001, LDL-C p<0.001, CRP p<0.001, HDL-C p<0.001). No differences between these groups in blood pressure and body mass index were found.
CONCLUSION: We conclude that the diet enriched with carp meat significantly improved plasma lipid parameters in patients after major cardiac revascularization surgery....
Adámková V, Kacer P, Mraz J, Suchanek P, Pickova J, Králova Lesná I, Skibova J, Kozak P, Maratka V. The consumption of the carp meat and plasma lipids in secondary prevention in the heart ischemic disease patients. Neuro Endocrinol Lett. 2011 Jan; 32(Suppl 2): 17-20
OBJECTIVE: The influence of thyroid hormones upon renin-angiotensin-aldosterone system is poorly understood. Under basal conditions, individuals belong to normal, low or high plasma renin activity (PRA) subjects. The study was designed to evaluate basal and poststimulatory PRA and serum aldosterone (Aldo) level in patients with hyperthyroidism or hypothyroidism during therapy.
MATERIAL AND METHODS: We examined 73 women with hyperthyroidism, 27 women with hypothyroidism and 36 healthy controls. The patients were investigated before initiation of therapy and after attainment of euthyroid state. All subjects were investigated under basal conditions (normal-sodium diet) and after application of a low-sodium diet for three days and upright position for 3 hr. PRA, serum Aldo level, blood pressure, serum sodium, potassium and thyroid hormone levels were determined in all subjects. The subjects were classified as low PRA (<1.0 ng/ml/h), normal PRA (1.0-4.0 ng/ml/h) and high PRA (>4.0 ng/ml/h) individuals according to results obtained under basal conditions.
RESULTS: Relatively higher poststimulatory enhancement in PRA was found in patients with hyperthyroidism, especially those with low basal PRA, than in those with hypothyroidism. In women with thyroid dysfunctions poststimulatory increase in Aldo were relative lower than poststimulatory enhancement of PRA. After therapy these difference disappeared. The poststimulatory changes in PRA depended on the basal PRA.
CONCLUSIONS: Poststimulatory PRA is higher in hyperthyroid women, especially those with low basal PRA. In women with hypothyroidism, basal and poststimulatory PRA is low. Blood pressure and severity of thyroid dysfunction was found to be similar in the patients with low, normal or high basic PRA. In women with thyroid dysfunctions, serum Aldo level and its relative poststimulatory increments are inadequate to changes of PRA; it is suggested that the dissociation in the renin-angiotensin-aldosterone system occurs in hyperthyroid and hypothyroid women....
Marcisz C, Kucharz E, Marcisz-Orzel M, Poręba R, Orzel A, Sioma-Markowska U. Changes of poststimulatory plasma renin activity in women with hyperthyroidism or hypothyroidism in relation to therapy. Neuro Endocrinol Lett. 2011 Jan; 32(3): 301-307
OBJECTIVE: Depression is a common disorder among diabetic patients and affects negatively the treatment of their basic disease. The aim of the study was to assess, whether antidepressant medication could positively influence glycemic control of diabetes type 1 in depressive or anxious patients.
METHODS: A six-month, double-blinded, randomized, placebo-controlled study was performed to investigate the reaction of type 1diabetic patients (n=21) to treatment of depression and anxiety symptoms using antidepressant drug sertraline. The patients were given sertraline (100 mg/day) or placebo. The evolution of mental change was assessed using Zung Self-Rating Depression Scale (SDS), Hamilton Anxiety Rating Scale (HAMA) and Hamilton Depression Rating Scale (HAMD) along with development of somatic parameters commonly assessed in diabetic patients, especially glycosylated hemoglobin, insulin dose and body weight. The level of active substance in serum of the patients was also measured.
RESULTS: Mental state improved at the level of statistical significance of p<0.001 in both patients using antidepressant and placebo. From somatic parameters, body weight and systolic blood pressure increased statistically significantly also in both groups of patients.
CONCLUSIONS: The mental state of most patients who successfully completed the study improved regardless of the fact if they were using antidepressant or placebo. No statistically significant connections between the mental and somatic changes were found. This finding points out to the placebo effect of the medication, to the importance of a contact with patients, but also to the need to concentrate on their mental state....
Komorousova J, Beran J, Rusavy Z, Jankovec Z. Glycemic control improvement through treatment of depression using antidepressant drugs in patients with diabetes mellitus type 1. Neuro Endocrinol Lett. 2010 Jan; 31(6): 801-806
...
Chronomics complement, among many other fields, genomics and proteomics. Neuro Endocrinol Lett. 2001 Jan; 22(1): 53-73