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Journal Article 2009; 30(1): 119-124 PubMed PMID: 19300390 Citation  Keywords:  Adult, Brain Mapping, Case-Control Studies, Cerebrum:pathology, Depression:complications, Diabetes Mellitus:pathology, Diabetic Neuropathies:complications, Dominance, Cerebral:physiology, Evoked Potentials, Visual, Female, Humans, Male, Middle Aged, Psych.   

OBJECTIVES: The present study was undertaken in order to verify the hypothesis stating that patients with depression exhibit some abnormalities concerning a cerebral symmetry. For this purpose, an analysis of the relationship between the VEPs (Visual Evoked Potentials) results and the depressive symptoms intensification, as well interrelation between depressive and diabetic symptoms were performed.

MATERIAL AND METHODS: VEPs recordings were obtained from the two study groups (both aged 20-45 years), 20 healthy subjects and 32 diabetic patients with clinically documented depression. The VEPs examination was carried out using a computer system called STELLA (Stimulated Electroencephalogram on Line Analyzer).

RESULTS: VEPs examinations revealed a cerebral symmetry in the all control subjects and in 10 out of 32 diabetic patients with depressive disorders. It is noteworthy that 22 of 32 diabetic patients (68.8%) showed a hemispheric asymmetry in the VEPs recordings. Of 12 patients with a moderate depression, 10 showed the left cerebral laterality, and 2--the right laterality. In turn, all 10 patients with major depressive disorder (MDD) demonstrated in the VEPs recordings a significant cerebral laterality with the right hemisphere dominance.

CONCLUSIONS: The obtained results suggest that interhemispheric cerebral asymmetry might be considered a specific feature of depression, and, if this is a case, it could justify a conclusion that right hemisphere dominance could be a neurophysiological marker of MDD. It should be emphasized that intensification of the depressive symptoms has an unfavorable influence on course of diabetes mellitus, its self-control and severity of following complications....

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Journal Article 2008; 29(2): 185-191 PubMed PMID: 18404136 Citation  Keywords:  Animals, Brain Diseases:etiology, Dominance, Cerebral:physiology, Endocrine System Diseases:etiology, Functional Laterality:physiology, Humans, Kindling, Neurologic:physiology, Neurosecretory Systems:physiopathology, Stress, Psychological:complications,.   

: Stressful life events cause a variety of conditions affecting cerebral and neuroendocrine functions. Repeated stressful events also may determine sensitization leading to an increase in responsiveness to stress stimuli. Recent findings suggest that cognitive and emotional dysregulation related to traumatic stress likely is linked to defective inhibitory functions that may also lead to temporo-limbic seizure-like activity, increased vulnerability to stressors, and dysregulated asymmetry in neural activity patterns that may influence interhemispheric dissociation. Together recent data show that dysregulation in the brain asymmetry and mental functioning may be caused by stress-related activation that can influence also the peripheral endocrine glands through the HPA axis and other pathways connecting the CNS and the target endocrine glands....

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