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Case Reports 2015; 36(1): 24-27 PubMed PMID: 25789591 Citation  Keywords:  Chelation Therapy:methods, Humans, Iron:metabolism, Iron Chelating Agents:therapeutic use, Male, Middle Aged, Parkinson Disease:drug therapy, Treatment Outcome,.   

: In this case presentation, a man with a diagnosis of Parkinson's disease was treated with Chelation Therapy against iron without iron serum level correlation. The patient, who suffered from motor and non-motor symptoms of the disease, showed an improved condition after the Therapy. This clinical test was evaluated with UPDRS III score. The rationale and the limits of the Therapy are discussed. This case suggests that iron-dependent oxidative stress could represent a promising therapy for this dramatic disease; the necessity to deeply study the iron metabolism in neuro-degeneration appears really significant....

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Clinical Trial 2006; 27(6): 833-838 PubMed PMID: 17187010 Citation  Keywords:  Adolescent, Androgen Antagonists:therapeutic use, Autistic Disorder:drug therapy, Chelating Agents:therapeutic use, Child, Child Behavior:drug effects, Cognition:drug effects, Female, Humans, Leuprolide:therapeutic use, Male, Metals, Heavy:urine, Severity.   

BACKGROUND: A medical hypothesis has suggested that some autism spectrum disorders (ASDs) may result from interactions between the methionine cycle-transsulfuration and androgen pathways following exposure to mercury.

METHODS: The IRB of the Institute for Chronic Illnesses approved the present study. A novel treatment was utilized combining LUPRON (leuprolide acetate, TAP Pharmaceuticals, Inc.) and CHEMET (meso-2, 3-dimercaptosuccinic acid--DMSA, McNeil Consumer Products Company) on 11 consecutive children with ASDs.

RESULTS: A significant (p<0.01) overall improvement from the 70-79th percentile of severity (median baseline score=87) at baseline to the 40-49th percentile of severity (median end of study period score=63) at the end of the study was observed for patients treated for a median of approximately 4 months. Significant improvements in sociability, cognitive awareness, behavior, and clinical symptoms/behaviors of hyperandrogenemia were also observed. Significant decreases in blood androgens and increases in urinary heavy metal concentrations were observed. Minimal drug adverse effects were found.

CONCLUSION: This study provides the first clinical evidence for the benefit that combined anti-androgen and anti-heavy metal therapy may have on some children with ASDs. Additional studies should examine androgen and heavy metal mechanisms of action in ASDs, and future ASD treatment protocols should consider androgens and heavy metals....

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Journal Article 2005; 26(5): 439-446 PubMed PMID: 16264412 Citation  Keywords:  Autistic Disorder:chemically induced, Autoimmune Diseases:chemically induced, Chelating Agents:therapeutic use, Child, Humans, Inflammation:chemically induced, Mercury:analysis, Mercury Poisoning:epidemiology,.   

: The causes of autism and neurodevelopmental disorders are unknown. Genetic and environmental risk factors seem to be involved. Because of an observed increase in autism in the last decades, which parallels cumulative mercury exposure, it was proposed that autism may be in part caused by mercury. We review the evidence for this proposal. Several epidemiological studies failed to find a correlation between mercury exposure through thimerosal, a preservative used in vaccines, and the risk of autism. Recently, it was found that autistic children had a higher mercury exposure during pregnancy due to maternal dental amalgam and thimerosal-containing immunoglobulin shots. It was hypothesized that children with autism have a decreased detoxification capacity due to genetic polymorphism. In vitro, mercury and thimerosal in levels found several days after vaccination inhibit methionine synthetase (MS) by 50%. Normal function of MS is crucial in biochemical steps necessary for brain development, attention and production of glutathione, an important antioxidative and detoxifying agent. Repetitive doses of thimerosal leads to neurobehavioral deteriorations in autoimmune susceptible mice, increased oxidative stress and decreased intracellular levels of glutathione in vitro. Subsequently, autistic children have significantly decreased level of reduced glutathione. Promising treatments of autism involve detoxification of mercury, and supplementation of deficient metabolites....

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