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The influence of scopolamine and extreme temperatures on the lipid level in some mouse organs.

Klusek J, Swiderska-Kołacz G, Jóźwik A, Kołataj A.
Comparative Study 2006; 27(3): 369-372 PubMed PMID: 16816828 Citation  Keywords:  Adaptation, Physiological:drug effects, Analysis of Variance, Animals, Cholesterol:metabolism, Cold Temperature, Female, Hot Temperature, Kidney:metabolism, Lipid Metabolism:drug effects, Lipids:blood, Liver:metabolism, Male, Mice, Muscarinic Antagonists:.   

OBJECTIVES: The effect of scopolamine administration at dose 0,5 g/kg b.w. and high (+40 degrees C) and low (+4 degrees C) temperature on the level of triacyloglycerides, total lipids and cholesterol in the mouse liver, kidney and muscle of males and females.

METHODS: The homogenates of the liver, kidney and muscle were taken for examination. The concentrations of triacyloglycerides, total lipids and cholesterol was estimated according to the Bio-La-Tests (Poland).

RESULTS: The concentration of triacyloglycerides and total lipids in the liver, kidney and muscle increased of males and females after scopolamine injections and after exposure to high and low temperatures.

CONCLUSION: Scopolamine may effect an increase in the rate of the lipid metabolism....

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