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Journal Article 2001; 22(1): 53-73 PubMed PMID: 11393163 Citation  Keywords:  Adrenal Glands:physiology, Animals, Biological Clocks, Blood Pressure:physiology, Chronobiology Disorders:physiopathology, Chronobiology Phenomena, Chronotherapy, Circadian Rhythm:physiology, Drug Administration Schedule, Genomics, Homeostasis, Humans, Pi.   

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Journal Article 2013; 34(4): 282-286 PubMed PMID: 23803873 Citation  Keywords:  Causality, Chronobiology Disorders:epidemiology, Epidemiologic Methods, Humans, Neoplasms:epidemiology, Work Schedule Tolerance:physiology,.   

: With their 2007 classification - shift work involving "circadian disruption" is probably carcinogenic to humans (Group 2A) - the International Agency for Research on Cancer [IARC] provided a riddle for scientists and the public alike. Thereafter, eighteen epidemiological investigations into shift work and a host of malignant endpoints (including cancers of the breast, prostate, lung, colon, rectum, pancreas, bladder, skin and non-Hodgkin lymphoma [NHL]) as well as mortality were published. Although IARC experts identified "circadian disruption" as the critical link in the "probable" chains of cancer causation, almost none of the post-IARC studies specifically considered a disturbed temporal organization of biology. This implies that epidemiological research to-date is less focused than it should be. To illustrate a potential chronobiological fallacy of past studies, we offer a thought experiment. In addition, we consider first empirical evidence from recent research which avoided such bias. Methodological perspectives for future chronobiology-driven epidemiological research are outlined....

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Journal Article 2001; 22(1): 53-73 PubMed PMID: 11393163 Citation  Keywords:  Adrenal Glands:physiology, Animals, Biological Clocks, Blood Pressure:physiology, Chronobiology Disorders:physiopathology, Chronobiology Phenomena, Chronotherapy, Circadian Rhythm:physiology, Drug Administration Schedule, Genomics, Homeostasis, Humans, Pi.   

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Historical Article 2012; 33(4): 357-360 PubMed PMID: 22936255 Citation  Keywords:  Chronobiology Discipline:history, Chronobiology Disorders, History, 20th Century, History, 21st Century, Humans, Terminology as Topic,.   

: Chronomedicine may be conceptualized as dealing with the prevention, causation, diagnosis, and treatment of diseases in humans with a particular focus on the role "time" [Greek: chrónos] plays in our physiology, endocrinology, metabolism and behavior at many organizational levels. While it has been used as a term and somewhat pursued as a discipline for decades, it appears that chronomedicine has captured a broader interest as a promising specialty only more recently. This commentary addresses roots of chronomedicine in the 1900s and perspectives for chronomedicine in the 21st century. Classical terms of chronobiology, e.g., Zeitgeber, melatonin and circadian, may be traced back to Aschoff, Lerner, and Halberg, respectively, but who actually coined the term "chronomedicine" and used it first in a publication remains unclear. Importantly, it could be(come) rather straightforward to transfer abundant insights gained from chronobiology to strategies in chronomedicine as animal models have been increasingly developed to understand human health and disease. Perspectively, chronomedicine should comprise "clinical chronomedicine" (individual-based) and "preventive chronomedicine" (population-based). Overall, due to the "maturing" of chronomedicine as a field, the near future might bring a section dedicated to chronomedicine in existing journals, or even a "Journal of Chronomedicine" as vectors of ideas and research....

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Journal Article 2010; 31(1): 1-3 PubMed PMID: 20150863 Citation  Keywords:  Biological Clocks:physiology, Biomedical Research:standards, Causality, Chronobiology Disorders:complications, Humans, Models, Theoretical, Neoplasms:epidemiology, Risk Factors,.   

: A cascade of investigations into the validity of the chronodisruption-cancer theory (CD-CT), proposed 2008 in Neuroendocrinology Letters as a synthesis of abundant experimental and tantalizing - but still limited - epidemiological data, can be expected in coming years. In view of the possible public health relevance of the suggested links between chronodisruption, defined as the disruption of the temporal organization or order of biological rhythmicity over days and seasons, and the development of disease, including cancer, we provide practical aspects which should be considered for the planning, conduct and the very interpretation of such studies. The interrelated considerations address two facets: first, the critical necessity of causal clarification can be evinced appropriately by Poole's earlier contribution to the Journal. Researchers into the validity of the CD-CT should certainly consider Poole's 2002 illustration via causal graphs for shift work, light at night and breast cancer of the subtleties that can arise in the use of exposure surrogates of different kinds. Second, we emphasize the importance of considering the Zeitgeber multiplicity to avoid causal reductionism in epidemiologic - but also other - chronodisruption research....

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Journal Article 2001; 22(1): 53-73 PubMed PMID: 11393163 Citation  Keywords:  Adrenal Glands:physiology, Animals, Biological Clocks, Blood Pressure:physiology, Chronobiology Disorders:physiopathology, Chronobiology Phenomena, Chronotherapy, Circadian Rhythm:physiology, Drug Administration Schedule, Genomics, Homeostasis, Humans, Pi.   

...

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Journal Article 2001; 22(1): 53-73 PubMed PMID: 11393163 Citation  Keywords:  Adrenal Glands:physiology, Animals, Biological Clocks, Blood Pressure:physiology, Chronobiology Disorders:physiopathology, Chronobiology Phenomena, Chronotherapy, Circadian Rhythm:physiology, Drug Administration Schedule, Genomics, Homeostasis, Humans, Pi.   

...

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Journal Article 2001; 22(1): 53-73 PubMed PMID: 11393163 Citation  Keywords:  Adrenal Glands:physiology, Animals, Biological Clocks, Blood Pressure:physiology, Chronobiology Disorders:physiopathology, Chronobiology Phenomena, Chronotherapy, Circadian Rhythm:physiology, Drug Administration Schedule, Genomics, Homeostasis, Humans, Pi.   

...

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