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Journal Article 2001; 22(1): 53-73 PubMed PMID: 11393163 Citation  Keywords:  Adrenal Glands:physiology, Animals, Biological Clocks, Blood Pressure:physiology, Chronobiology Disorders:physiopathology, Chronobiology Phenomena, Chronotherapy, Circadian Rhythm:physiology, Drug Administration Schedule, Genomics, Homeostasis, Humans, Pi.   

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Journal Article 2009; 30(4): 458-461 PubMed PMID: 20010497 Citation  Keywords:  Animals, Blood Glucose:metabolism, Circadian Rhythm:physiology, Dietary Sucrose:pharmacology, Drinking Behavior:physiology, Eating:physiology, Hemoglobin A, Glycosylated:metabolism, Hyperglycemia:genetics, Lipids:blood, Male, Mice, Mice, Inbred ICR, Obesi.   

BACKGROUND: The environmental light-dark (LD) cycle entrains the circadian clock located in the suprachiasmatic nucleus (SCN) of mammals. Recent studies of genetically impaired animals with clock gene mutations have revealed associations between metabolic disorders and the circadian clock. However, whether such disordered phenotypes are due to a loss of circadian clock function within specific metabolically relevant tissues, or the result of disrupted circadian behavioral activities governed by the SCN remains unknown.

OBJECTIVES: The present study examines the effect of disrupted LD cycles that might perturb the circadian clock in the SCN and peripheral organs on a high-fat/high-sucrose diet-induced obesity in genetically intact mice.

METHODS: The behavioral patterns of the mice were disturbed under an ultradian 3 h light-3 h dark cycle (LD 3:3) due to light-induced direct suppression of the behavior (masking effect).

RESULTS: Obesity with hyperglycemia was significantly enhanced and levels of hemoglobin A1c were significantly higher under LD 3:3 compared with LD 12:12.

CONCLUSIONS: These findings provide a link between metabolic disorders and the "environmental mutation" in genetically intact animals....

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Journal Article 2001; 22(1): 53-73 PubMed PMID: 11393163 Citation  Keywords:  Adrenal Glands:physiology, Animals, Biological Clocks, Blood Pressure:physiology, Chronobiology Disorders:physiopathology, Chronobiology Phenomena, Chronotherapy, Circadian Rhythm:physiology, Drug Administration Schedule, Genomics, Homeostasis, Humans, Pi.   

...

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Journal Article 2001; 22(1): 53-73 PubMed PMID: 11393163 Citation  Keywords:  Adrenal Glands:physiology, Animals, Biological Clocks, Blood Pressure:physiology, Chronobiology Disorders:physiopathology, Chronobiology Phenomena, Chronotherapy, Circadian Rhythm:physiology, Drug Administration Schedule, Genomics, Homeostasis, Humans, Pi.   

...

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Journal Article 2008; 29(Suppl 1): 33-64 PubMed PMID: 19029878 Citation  Keywords:  Circadian Rhythm:physiology, Depressive Disorder:therapy, Humans, Light:adverse effects, Phototherapy:adverse effects, Seasonal Affective Disorder:therapy, Seasons,.   

: Bright light is a treatment of choice for seasonal affective disorder. Other indications for bright light therapy have also been tested. These include non-seasonal depression, bipolar depression, chronic depressive disorder, ante- and postpartum depression, late luteal phase dysphoric disorder, circadian phase sleep disorders, jet lag, shift work problems, and behavioral disturbance and insomnia in organic dementia. Future studies should focus on exploring the use of light therapy in combination with sleep deprivation, other classes of antidepressants, and with psychotherapy and their possible combined effect on subtypes of depression or other mentioned diagnoses, light treatment duration, and the applicability and efficacy of adjunct light treatment for in-patients....

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Journal Article 2008; 29(Suppl 1): 65-92 PubMed PMID: 19029872 Citation  Keywords:  Antipsychotic Agents:therapeutic use, Circadian Rhythm:physiology, Clinical Trials as Topic, Combined Modality Therapy, Depressive Disorder:physiopathology, Flumazenil:therapeutic use, GABA Modulators:therapeutic use, Humans, Lithium Compounds:therapeutic.   

: Sleep deprivation is a useful therapeutic option in the treatment of depressive disorders, especially in pharmacoresistant disorders. Its therapeutic efficacy in other indications has not, however, been confirmed. According to current knowledge, application of sleep therapy requires concomitant therapy to prevent early relapses of depression. Total sleep deprivation is the classic variant of its clinical use. Partial sleep deprivation has a somewhat less pronounced antidepressant effect, and the duration of sleep deprivation rather than application timing determines its therapeutic effect. The most reliable predictors of sleep deprivation efficacy are marked diurnal fluctuations of depressive mood, patient locomotor activity, and limbic hyperactivity in the central nervous system. The mechanism of the antidepressant effect of sleep deprivation remains unknown....

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Journal Article 2008; 29(1): 159-162 PubMed PMID: 18283263 Citation  Keywords:  Adrenocorticotropic Hormone:blood, Animals, Body Weight:physiology, Central Nervous System:physiology, Circadian Rhythm:physiology, Corticosterone:blood, Entorhinal Cortex:physiology, Hypothalamo-Hypophyseal System:physiology, Male, Pituitary-Adrenal Syst.   

OBJECTIVE: In our previous study, a lesion in the entorhinal cortex was found to significantly attenuate the elevation of adrenocorticotropic hormone (ACTH) in plasma during immobilization stress. The aim of the present study was to investigate whether the entorhinal cortex exerts a modulatory effect on circadian ACTH and corticosterone release.

MATERIALS AND METHODS: Ibotenic acid (15 microg/microl) was stereotaxically bilaterally injected into the entorhinal cortex of rats. Two weeks after the injections, ACTH and corticosterone levels in plasma were measured at 0800 h, 1300 h and 1800 h.

RESULTS: Compared with sham-operated control rats, rats with entorhinal cortex lesions produced by ibotenic acid showed either significantly elevated plasma ACTH or plasma corticosterone levels at 0800 h, but no difference at 1300 h or 1800 h.

CONCLUSION: The results of the present study indicate that the entorhinal cortex plays a certain role in the regulation by the central nervous system of the circadian rhythm of the hypothalamic-pituitary-adrenal (HPA) axis....

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Controlled Clinical Trial 2008; 29(1): 168-172 PubMed PMID: 18283250 Citation  Keywords:  Adult, Affect:physiology, Anorexia Nervosa:physiopathology, Appetite:physiology, Body Temperature:physiology, Bulimia Nervosa:physiopathology, Circadian Rhythm:physiology, Eating:physiology, Female, Humans, Hunger:physiology, Phototherapy:methods,.   

OBJECTIVES: Light and food are important synchronizers of circadian rhythmicity. In eating disorders, the circadian rhythms of food intake and temperature are abnormal.

METHODS: We analyzed the effect of the morning light application on the circadian rhythm of tympanic temperature and its association with hunger and mood changes in the sample of 25 female patients hospitalized with DSM-IV diagnosis of eating disorders (14 bulimia nervosa and 11 anorexia nervosa) and in 6 healthy women.

RESULTS: Light therapy reduced interindividual variability of the temperature acrophase, synchronized the temperature and hunger rhythms and showed an antidepressant effect on patients with eating disorders. Bright light therapy normalized the circadian rhythm of body temperature in both anorexic and bulimic patients: phase advanced rhythm was delayed and phase delayed rhythm was advanced. In contrast with anorexic patients, the majority of bulimic patients had normal temperature rhythm before the therapy and this rhythm was not changed by the therapy.

CONCLUSION: The light therapy normalized temperature circadian rhythm in patient with eating disorders. We hypothesize that the light therapy can also contribute to improvement of pathological eating pattern because of the functional connections between light and food entrained oscillators. The light may help to restore the irregular circadian rhythmicity induced by chaotic food intake....

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