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Journal Article 2011; 32(3): 349-353 PubMed PMID: 21712777 Citation  Keywords:  Adipokines:blood, Body Mass Index, Cross-Sectional Studies, Diabetes Complications:blood, Female, Hemoglobin A, Glycosylated:metabolism, Humans, Male, Middle Aged, Obesity:blood, Resistin:blood, Sex Characteristics,.   

OBJECTIVE: Glycosylated hemoglobin (HbA1c) and resistin may be influenced by diabetes, but their associations remain unclear. We hypothesized that serum resistin might be parallel to Hb1c.

DESIGN AND SETTING: We measured serum resistin in 134 obese non-diabetic (73 women and 61 men), and 65 obese diabetic (33 women and 32 men) humans, and examined their relationships with HbA1c. The presence of diabetes was the only differentiating factor between the groups.

RESULTS: Resistin, non-diabetic vs. diabetic, median and interquartile range, respectively: resistin (ng/mL) 26.08, 16.09 and 22.14,14.54, p>0.5. To investigate the influence of HbA1c on resistin, both groups were divided into tertiles based on HbA1c. In diabetics, resistin was similar in high, intermediate, and low HbA1c subgroups, p>0.05, and resistin was not influenced by HbA1c: r=-0.1785; p=0.15. In non-diabetics, resistin differed between HbA1c tertiles, p<0.001, and was influenced by HbA1c, r = -0.3599; p=0.0003.

CONCLUSIONS: Resistin concentrations are similar in diabetic and non-diabetic humans with the same range of obesity. However, resistin is associated with HbA1c only in non-diabetic obese individuals which may point to the fact that resistin is a marker of glycaemic balance in obesity but not in diabetes....

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Journal Article 2010; 31(2): 270-274 PubMed PMID: 20424586 Citation  Keywords:  Adult, Blood Glucose:metabolism, Diabetes Complications:blood, Fasting:blood, Female, Hemoglobin A, Glycosylated:metabolism, Humans, Hyperprolactinemia:blood, Magnetic Resonance Imaging, Male, Middle Aged, Pituitary Gland:pathology, Prevalence, Prolactin:.   

OBJECTIVE: Prolactin levels have been shown to be reduced in poorly controlled diabetes mellitus; however, diabetic patients with high prolactin levels may be seen in clinical practice. The aim of this study was to evaluate diabetic patients with hyperprolactinemia, and to determine the role of macroprolactinaemia in these patients.

MATERIALS AND METHODS: The study included 174 patients (153 women and 21 men) with hyperprolactinemia, retrospectively reviewed over a 2 years period. Data on presenting symptoms, the presence of diabetes mellitus, prolactin levels, macroprolactin levels, pituitary magnetic resonance imaging were collected in all patients. In addition; HbA1c, fasting blood glucose levels and postprandial glucose levels were collected in diabetic patients.

RESULTS: Of the 174 patients, 27 were diagnosed with diabetes mellitus (15.5%). Eighteen of the diabetic patients with hyperprolactinaemia had macroprolactinaemia (66.6%). The prevalence of macroprolactinaemia in diabetic patients is higher than the non-diabetic population (66.6% vs. 39.5%, p=0.009). In diabetic patients with macroprolactinaemia, HbA1c levels were higher than the diabetic patients without macroprolactinaemia.

CONCLUSION: The prevalence of macroprolactinaemia in diabetic patients was higher than the non-diabetic population. It seems necessary to determine macroprolactin levels in diabetic patients with hyperprolactinaemia; and in this case, further diagnostic evaluation is not warranted....

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Journal Article 2008; 29(3): 373-378 PubMed PMID: 18580854 Citation  Keywords:  Acromegaly:physiopathology, Adult, Aged, Diabetes Complications:physiopathology, Electroencephalography, Evoked Potentials, Auditory, Brain Stem:physiology, Female, Functional Laterality:physiology, Humans, Male, Middle Aged, Prediabetic State:physiopatho.   

OBJECTIVES: Acromegaly is associated by various systemic complications, involving also the nervous system. Other studies revealed peripheral but not central nervous system impairment with somatosensory evoked potentials examinations in acromegaly. Aim of the present study was to assess whether brainstem transmission in acromegaly is disturbed.

MATERIAL AND METHODS: The study was carried out in 37 patients. The control group consisted of 47 healthy persons. In all of the subjects, peripheral transmission, reflected by peak I latency, and brainstem transmission, tested by interpeak latency I-V (IPL I-V), were examined.

RESULTS: Peak I latency was delayed in 6 out of 37 patients (1 - bilaterally, 2 - right side, 3 - left side). The group-mean latency of peak I was 1.53 msec and 1.56 msec, for the right and left side, respectively. There were found no statistically significant differences between the right and left side, likewise in comparison with control group. In turn, as compared with the controls, IPL I-V was disturbed in 25 out of 37 patients: in most of the cases IPL I-V prolongation was observed (8 - bilateral prolongation, 11 - right side, 6 - left side). Moreover, the statistically significant difference between the brainstem sides (4.27 vs. 4.11 msec; p<0.05) was observed.

CONCLUSION: In the examined patients with acromegaly, there was no peripheral disturbance in transmission, as examined by BAEPs registrations. Conversely, in nearly half of the patients with acromegaly, brainstem transmission was found to be delayed, and significant difference between responses from the both sides of the brainstem were noted....

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Journal Article 2007; 28(Suppl 3): 33-34 PubMed PMID: 18030276 Citation  Keywords:  Anti-Bacterial Agents:therapeutic use, Community-Acquired Infections:drug therapy, Diabetes Complications:drug therapy, Diabetes Mellitus, Humans, Meningitis, Bacterial:drug therapy, Outcome Assessment (Health Care), Oxacillin:therapeutic use, Staphylococ.   

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Journal Article 2007; 28(Suppl 3): 28-29 PubMed PMID: 18030274 Citation  Keywords:  Anti-Bacterial Agents:therapeutic use, Cefotaxime:therapeutic use, Cohort Studies, Community-Acquired Infections:microbiology, Diabetes Complications:immunology, Diabetes Mellitus:immunology, Humans, Meningitis, Bacterial:etiology, Outcome Assessment (Hea.   

: Community acquired bacterial (CBM) meningitis in diabetic patients was analyzed for risk factors and outcome in a cohort of 201 cases of meningitis within last 17 years: 15 patients with diabetes mellitus and meningitis were identified and compared for etiology and mortality as well as for neurologic sequellae with all CBM cases....

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Comparative Study 2007; 28(Suppl 3): 25-26 PubMed PMID: 18030272 Citation  Keywords:  Bacteremia:complications, Bacteria:isolation & purification, Community-Acquired Infections:complications, Diabetes Complications:microbiology, Diabetes Mellitus:microbiology, Humans, Meningitis, Bacterial:complications, Outcome Assessment (Health Care), R.   

: Meningitis associated with bacteremia is rare. Bacteremic form of meningitis occurred in 28 of 201 cases of community acquired meningitis (14%) in Slovakia within last 17 years. Bacteremic meningitis was associated with diabetes (21.4% vs. 7.5%, p=0.02) and with higher treatment failures (32.1% vs. 9.5%, p=0.01) and higher mortality (25% vs. 12.4%, NS). In univariate analysis comparing 28 cases of bacteremic community acquired bacterial meningitis (BCBM) to all CBM, no significant risk factor concerning underlying disease (cancer, ENT infection, alcohol abuses, trauma, splenectomy, etc.) or etiology was observed apart of diabetes mellitus, which was more common among bacteremic meningitis (21.4% vs. 7.5%, p=0.02). Mortality (25% vs. 12.4%, NS) insignificantly but therapy failure (32.1% vs. 9.5%, p=0.01) was significantly more frequently observed among meningitis with bacteremia. N. meningitis was the commonest causative agent (8 of 28 cases) followed by Str. pneumoniae (6), gram-negative bacteria (6), S. aureus (4) and H. influenzae (2)....

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Journal Article 2007; 28(Suppl 3): 14-15 PubMed PMID: 18030266 Citation  Keywords:  Alcohol-Related Disorders:complications, Anti-Bacterial Agents:therapeutic use, Community-Acquired Infections:etiology, Diabetes Complications, Humans, Meningitis, Bacterial:etiology, Otitis Media:complications, Outcome Assessment (Health Care), Risk Fact.   

: We investigated how many cases of bacterial meningitis in our national survey were associated with sinusitis or otitis media. Among 372 cases of bacterial meningitis within our nationwide 17 years survey, 201 cases were community acquired (CBM) and in 40 (20%) otitis media or sinusitis acuta/chronica were reported 1-5 weeks before onset of CBM. Diabetes mellitus (20% vs. 7.5%, p=0.01), alcohol abuse (35% vs. 15.4%, p=0.003) and trauma (30% vs. 14.9%, p=0.02) were significantly associated with CBM after ENT infections. Concerning etiology, CBM after sinusitis/otitis was insignificantly associated with pneumococcal etiology (50% vs. 33.8 %, NS) and significantly associated with other (L. monocytogenes, Str. agalactiae) bacterial agents (9.9 % vs. 25 %, p=0.008) . However those significant differences for new ENT related CBM had no impact on mortality (12.4 % vs. 5%, NS), failure after initial antibiotics (10 % vs. 9.5%, NS) and neurologic sequellae (12.5 % vs. 15.4 %, NS)....

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Journal Article 2006; 27(1-2): 281-287 PubMed PMID: 16648811 Citation  Keywords:  Analgesics, Animals, Antidepressive Agents, Second-Generation:pharmacology, Blood Glucose:metabolism, Diabetes Complications:drug therapy, Diabetes Mellitus, Experimental:blood, Female, Fluoxetine:pharmacology, Hyperalgesia:drug therapy, Male, Mice, Mice,.   

OBJECTIVES: Clinical and experimental trials have demonstrated that some of selective serotonin reuptake inhibitors (SSRIs) have some suspicious effects on blood glucose levels in different directions. Especially fluoxetine and sertraline are studied in this point of view. These drugs are also used in treatment of depression and peripheral neuropathy in diabetic patients. Paroxetine and fluoxetine, members of this drug group, besides having antidepressant effects were shown to have antinociceptive effects in animals and humans. They can be used in the treatment of chronic pain as an adjuvant drug or alone. But less is known about their actions on pain in case of diabetes. The aim of this study is to investigate the antinociceptive effects of fluoxetine and paroxetine in diabetic and non-diabetic mice while monitoring their effects on blood glucose levels.

METHODS: Mice of either sex were randomly used in experiments. The antinociceptive effects of paroxetine and fluoxetine were evaluated using hot plate test both in diabetic and non-diabetic mice. The effects of these drugs on blood glucose levels were also evaluated in another group of mice both in diabetic and non-diabetic mice.

RESULTS: Fluoxetine and paroxetine showed significant antinociceptive effect at all doses and at all times tested in non-diabetic mice, but they could not successfully show this effect in diabetic mice. They also had controversial effects on blood glucose levels.

CONCLUSION: Although they showed increasing or decreasing effects on blood glucose levels in non-diabetic and diabetic mice, they showed antinociception on hot-plate test showing dissociation between blood glucose levels and analgesia....

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