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Coincidence of spinal tumor (astrocytoma) and non-specific encephalomyelitis.

Burgetova A, Vaneckova M, Nytrova P, Matej R, Seidl Z.
Case Reports 2012; 33(8): 769-772 PubMed PMID: 23391981 Citation  Keywords:  Adult, Astrocytoma:complications, Biopsy, Diagnosis, Differential, Encephalomyelitis:complications, Fatal Outcome, Humans, Magnetic Resonance Imaging, Male, Spinal Neoplasms:complications,.   

: The aim of this paper is to demonstrate that differential diagnostics of intra-medullary spinal lesions can sometimes be very difficult, even when the latest complement examinations are used, including magnetic resonance imaging. The particular case dealt with here was complicated by the presence of two different pathological processes. We present the case report, where the case history, clinical course and results of the paraclinical examinations, including the magnetic resonance imaging, suggested an intra-medullary inflammatory/demyelinating process. The post-mortem histological finding was a surprise, because besides signs of non-specific encephalomyelitis, it also displayed signs of a spinal tumor (histological character of diffuse astrocytoma grade II-III). We would like to emphasize some important facts in our discussion, especially from the perspective of the magnetic resonance imaging. Finally, we would like to ask if the presence of both pathologies (astrocytoma and nonspecific myelitis) was coincidental, or if the myelitis had an iatrogenic etiology (by therapy, by infection during the lumbar punctions)....

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Serum testosterone and corticosterone levels in acute experimental autoimmune encephalomyelitis (EAE) in male Wistar rats.

Macció D, Calfa G, Volosín M, Roth G.
Journal Article 2004; 25(3): 196-200 PubMed PMID: 15349085 Citation  Keywords:  Acute Disease, Animals, Corticosterone:blood, Encephalomyelitis, Autoimmune, Experimental:blood, Male, Rats, Rats, Wistar, Testosterone:blood, Time Factors,.   

OBJECTIVES: Experimental autoimmune encephalomyelitis (EAE) was induced to investigate the levels of circulating total testosterone (TT) and the possible association of corticosterone with the steroid-producing capacity of the testes.

SETTING AND DESIGN: We determined gonad weights, serum TT and corticosterone levels during the development of EAE in male rats.

METHODS: Active EAE was induced in young male Wistar rats by injection of whole myelin in complete Freund's adjuvant. All the rats were weighted and monitored daily for clinical signs and blooded during different phases of the disease. Serum TT was measured by radioimmunoassay and circulating corticosterone was determined using a competitive enzyme immunoassay. Also testes and seminal vesicles were removed to determine their weights.

RESULTS: Seminal vesicle weights and serum TT levels diminished during the acute stage of the disease in all EAE rats and then they began gradually to increase, reaching the normal values at the post-recovery phase. Concomitantly a significant increase in serum corticosterone levels was observed during the acute EAE and the post-recovery phase was accompanied by a decline in corticosterone levels.

MAIN FINDING: Our results indicated an inverse correlation between serum TT and corticosterone levels during the acute EAE. Moreover, the diminution of TT was not a consequence of an alteration of the testes induced by anti-myelin antibodies neither contributed by apoptosis of testis cells by exposure to corticosterone.

CONCLUSIONS: The negative correlation between corticosterone and TT levels associated to EAE may be relevant in understanding the association of the endocrine system and the development of autoimmune demyelinating diseases....

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