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P300 wave: a comparative study of impulsive aggressive criminals.

Zukov I, Hrubý T, Kozelek P, Ptácek R, Paclt I, Harsa P.
Journal Article 2008; 29(3): 379-384 PubMed PMID: 18580845 Citation  Keywords:  Adult, Aggression:physiology, Alpha Rhythm, Analysis of Variance, Crime:psychology, Czech Republic, Electroencephalography, Event-Related Potentials, P300:physiology, Heart Rate:physiology, Humans, Impulsive Behavior:physiopathology, Male, Middle Aged, Ne.   

: Event-Related potentials are a simple non-invasive neurophysiological method enabling to comprehend certain aspects of the cognitive processing of information in humans. The best-known component of Event-Related Potentials is the so-called P3 wave. Alterations in the parameters of P300 wave have been discovered in certain personality disorders and in persons with impulsively aggressive behaviour. The purpose of this study is to investigate the changes of these parameters, especially an amplitude and latency in the place of Pz electrode. We examined 15 persons with the impulsive aggressive behaviour and compared them to a population comparable of normal age, gender and approximate degree of education. We used P300 auditory and a neuropsychological Eysenck IVE battery. The results showed that significantly lower amplitudes had been found in the aggressive impulsive subjects as compared to the control group. No statistically significant differences have been discovered in the latency. These results seem to confirm previous studies....

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Event related P300 potential in NIDDM patients without cognitive impairment and its relationship with previous hypoglycemic episodes.

Hissa M, D'Almeida J, Cremasco F, de Bruin V.
Journal Article 2002; 23(3): 226-230 PubMed PMID: 12080283 Citation  Keywords:  Adult, Aged, Brain:physiopathology, Cognition, Diabetes Mellitus, Type 2:physiopathology, Diabetic Retinopathy:physiopathology, Event-Related Potentials, P300, Female, Humans, Hypoglycemia:physiopathology, Male, Middle Aged,.   

OBJECTIVES: The purpose of this study was to evaluate the ERP P300 in non insulin dependent diabetes mellitus (NIDDM) patients without cognitive impairment and the relationship with clinical variables, the presence of retinopathy and previous hypoglycemic episodes.

METHODS: NIDDM patients (N=44) without evidence of cognitive impairment and controls (N=17) were studied clinically and with ancillary exams and the ERPs P300 were recorded. Patients were examined clinically and with the Folstein Mini-Mental Examination (MMSE) for cognitive function and all patients showed a score higher than 26 (maximal value=30). Previous hypoglycemia was evaluated through a questionnaire establishing the number of episodes and the symptoms of hypoglycemia in a scale scoring from zero to 15.

RESULTS: ERP P300 latencies were significantly higher in NIDDM patients than in controls (p<0.03). ERP P300 measures were significantly related to age (Pearson, p<0.01) and not to metabolic variables, disease duration or the presence of retinopathy. Severity of hypoglycemia was not associated to ERP P300 latency.

CONCLUSIONS: Our study supports the evidence that NIDDM patients, without signs of nervous system involvement, have ERP P300 alterations and this is not related to retinopathy, metabolic variables or previous hypoglycemic episodes. Chronic hyperglycemia may alter brain glucose transport and increase tolerance to hypoglycemia effects in the nervous system....

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