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Effect of melatonin administration on activities of some lysosomal enzymes in the mouse.

Witek B, Ochwanowska E, Kolataj A, Slewa A, Stanislawska I.
Journal Article 2001; 22(3): 181-185 PubMed PMID: 11449196 Citation  Keywords:  Acetylglucosaminidase:metabolism, Animals, Antigens, CD13:metabolism, Cathepsin D:metabolism, Cathepsin L, Cathepsins:metabolism, Cysteine Endopeptidases, Female, Glucuronidase:metabolism, Kidney:enzymology, Kinetics, Lipase:metabolism, Liver:enzymology, .   

OBJECTIVES: Changes in the activity of beta-glucuronidase, N-acetyl-beta-glucosaminidase, cathepsin D and L, alanine aminopeptidase and lysosomal acid lipase in lysosomal fractions of the liver and kidneys of mice, which were administered 20 mg/kg b.w. of exogenous melatonin (N-acetyl-5-methoxytryptamine) for 7 and 14 days were investigated.

METHODS: The slices of the liver and kidney were homogenized in 0.1M phosphate buffer, pH 7.0. Homogenates were subjected to differentiated centrifuging and determination of studied enzymes.

RESULTS: Melatonin caused lowering of the activity of all the investigated lysosomal enzymes in the liver and kidney.

CONCLUSION: Administration of melatonin was caused the lowering of the activity of the investigated lysosomal enzymes in comparison with values in control groups....

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Neuroendocrine aspects of anorexia nervosa and bulimia nervosa.

Baranowska B, Kochanowski J.
Journal Article 2018; 39(3): 172-178 PubMed PMID: 30431742 Citation  Keywords:  Adipose Tissue:metabolism, Anorexia Nervosa:metabolism, Appetite, Bulimia Nervosa:metabolism, Ghrelin:metabolism, Glucuronidase:metabolism, Gonads:metabolism, Human Growth Hormone:metabolism, Humans, Hypothalamo-Hypophyseal System:metabolism, Insulin-Like.   

: Endocrine dysfunctions in eating disorders (anorexia nervosa, bulimia nervosa) result from disturbed regulation of hypothalamo-pituitary-gonadal, hypothalamo-pituitary-adrenal, hypothalamo-pituitary-thyroid and hypothalamo-pituitary-GH-IGF1 axes as well as of altered peripheral endocrine metabolism. Some peptides of hypothalamic origin, as well as those secreted by the adipose tissue and gastrointestinal tract including pancreatic hormones, are involved in the control of appetite and satiety. These peptides play also an important role in the mechanism of hormonal secretion. Altered activity of these biologically active substances may lead to the disturbances in the regulation of energy and hormonal homeostasis....

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