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Journal Article 2001; 22(1): 53-73 PubMed PMID: 11393163 Citation  Keywords:  Adrenal Glands:physiology, Animals, Biological Clocks, Blood Pressure:physiology, Chronobiology Disorders:physiopathology, Chronobiology Phenomena, Chronotherapy, Circadian Rhythm:physiology, Drug Administration Schedule, Genomics, Homeostasis, Humans, Pi.   

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Journal Article 2001; 22(1): 53-73 PubMed PMID: 11393163 Citation  Keywords:  Adrenal Glands:physiology, Animals, Biological Clocks, Blood Pressure:physiology, Chronobiology Disorders:physiopathology, Chronobiology Phenomena, Chronotherapy, Circadian Rhythm:physiology, Drug Administration Schedule, Genomics, Homeostasis, Humans, Pi.   

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Comparative Study 2008; 29(6): 889-894 PubMed PMID: 19125151 Citation  Keywords:  Adolescent, Body Height, Child, Circadian Rhythm, Female, Growth Disorders:blood, Humans, Longitudinal Studies, Male, Periodicity, Prolactin:blood, Reproducibility of Results,.   

OBJECTIVES: In normal conditions, prolactin (Prl) secretion manifests a circadian pattern. So far, there have only been but few studies, concerning intrasubject variability and repeatability of the circadian Prl secretion pattern, based on pulse analysis. It seems, that macroscopic analysis based on measurement of Prl concentration at nine time points every 3 hours during 24 hours is an appropriate method to assess Prl profile for clinical purposes. The aim of the study was to assess the repeatability of that circadian Prl secretion pattern in a group of short children without hormonal disorders.

MATERIALS AND METHODS: The analysis comprised the results of two circadian Prl profiles, performed from 2 to 14 months in 23 prepubertal children (16 boys) with idiopathic short stature, aged: 10.3+/-2.4 yrs.

RESULTS: There were no statistical differences between Prl concentrations at the same time points in the two consecutive profiles, but the comparison of Prl concentrations at 8:00 gave results which were close to the border of statistical significance (p=0.055), what indicated low repeatability of measurement results at that particular time point. There were no statistical differences between the values of particular parameters in macroscopic profile analysis in the first and in the second test.

CONCLUSION: Circadian Prl profile, based on nine Prl concentration measurements, taken every 3 hours during one day, is characterized by high repeatability of the results and low intrasubject variability in children, despite the results of Prl concentration at 08:00 o'clock....

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Case Reports 2008; 29(6): 874-876 PubMed PMID: 19112420 Citation  Keywords:  Aged, Anti-Inflammatory Agents:therapeutic use, Autoimmune Diseases:complications, Azathioprine:therapeutic use, Diabetes Insipidus:etiology, Female, Humans, Hypothalamic Diseases:complications, Immunosuppressive Agents:therapeutic use, Methylprednisolone.   

: Autoimmune hypothalamitis is a rare autoimmune neuroendocirne disease. A case of a 70-year-old female with autoimmune hypothalamitis was reported. The chief clinical characteristics were diabetes insipidus and adenopituitary function deficiency. Cranial magnetic resonance imaging (MRI) scan indicated a mass in the hypothalamus. The diagnosis of autoimmune hypothalamitis was presumed. After treatment with prednisone, there was a marked reduction in the mass and the hypothalamus-adenopituitary function partially improved. However, after glucocorticoid therapy was withdrawn, the hypothalamic lesion relapsed progressively. High dose methylprednisolone pulse therapy (HDMPT) in combination with azathioprine was initiated thereafter. During follow-up, MRI scan indicated the lesion shrank strikingly, and the patient's clinical condition improved as well. In view of the good response of the hypothalamic lesion to glucocorticoid and immunodepressant, the putative diagnosis of autoimmune hypothalamitis was confirmed. This case report suggested that HDMPT in combination with azathioprine therapy might be an effective trial for autoimmune hypothalamitis treatment....

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Journal Article 2008; 29(6): 815-821 PubMed PMID: 19112419 Citation  Keywords:  Animals, Chronobiology Disorders:complications, Circadian Rhythm, Humans, Melatonin:physiology, Neoplasms:etiology,.   

: For two decades, research has been suggested and conducted into the causation and development of cancers in seemingly diverse and unrelated populations such as blind individuals, shift-workers, flight personnel, Arctic residents and subsets of sleepers. One common denominator of these investigations is "melatonin". Another common denominator is that all these studies implicitly pursued the validity of the so-called "melatonin hypothesis", of a corollary and of associated predictions which can be united in our proposed theory of "carcinogenesis due to chronodisruption". The new theory suggests that the various predictions investigated between 1987 and 2008 represent different aspects of the same problem. Indeed, abundant experimental evidence supports the notion that the final common cause of many cases of cancer may be what has been termed chronodisruption (CD), a relevant disturbance of the temporal organization or order of physiology, endocrinology, metabolism and behaviour. While melatonin as a key time messenger and time keeper can be a marker of CD, it is probably only partially related to the differential cancer occurrence apparent in individuals who chronically or frequently experience an excess or deficit of chronodisruption....

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Journal Article 2008; 29(6): 965-970 PubMed PMID: 19112417 Citation  Keywords:  Adolescent, Adult, Cross-Cultural Comparison, Female, Headache Disorders:classification, Humans, Migraine Disorders:classification, Migraine with Aura:diagnosis, Pakistan:epidemiology, Prevalence, Severity of Illness Index, Surveys and Questionnaires, You.   

: The International Headache Society (IHS) criteria-based questionnaires were given to 647 college-going females (faculty and students) of selected universities in Lahore, Pakistan. Forty five (7%) were diagnosed with Migraine with Aura (MWA), 181 (28%) with Migraine without Aura (MWOA) and 421 (65%) as NMH (non-migrainous headache). We found 'Photophobia and Phonophobia' as the most common headache-associated symptoms, and 'Stress' and lack of sleep' as the most commonly reported triggers of MWA (44%) and MWOA (38%). Most common headache management practice amongst migraineurs was 'sleep' [MWA (35%) and MWOA (39%)]. This is the first paper which elucidates the symptomatology, risk factors and treatment modalities of migraineurs in Pakistan....

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Case Reports 2008; 29(6): 857-866 PubMed PMID: 19112416 Citation  Keywords:  Antineoplastic Combined Chemotherapy Protocols:therapeutic use, Biological Therapy:methods, Breast Neoplasms:therapy, Carcinoma, Ductal, Breast:therapy, Complementary Therapies, Female, Hormone Antagonists:administration & dosage, Humans, Middle Aged, Neo.   

: In this case presentation, a woman with breast carcinoma who chose to try Prof. L. DiBella's biological therapy (MDB), was found, after seven months, to have a 50% reduction in objective measures of her carcinoma and was totally cured after 14 months. The patient's recovery extended to bilateral axillary adenopathies, and took place without the toxicity normally associated with cancer treatment. MDB entails the use of anti-proliferative molecules such as somatostatine, prolactin, and estrogen inhibitors, along with differentiating and apoptotic molecules such as melatonin, retinoids, vitamins C, D3, and E, calcium, and amino-sugars, combined with minimal doses of chemotherapy. The hemato-chemical exams showed no damage, with a progressive reduction of prolactin, estradiol, IGF1, and maintenance of low levels of GH. The achievement of objective results, without toxicity, in this case, proves the effectiveness of this therapy and confirms the positive results already published on the use of MDB for Low-Grade NHL, and pulmonary carcinomas in the 3rd and 4th stages. MDB, without the need for either hospitalization or day hospitalization, without toxicity, and without even minimally reducing the patient's daily work routine, allowed the patient to avoid surgical trauma and the significant collateral effects of chemo- and radiotherapy. Timely use of MDB as the first line therapy, in a patient which had not been debilitated by the mutagenic, toxic, and immuno-depressive effects of chemo- and radiotherapy, contributed greatly to the final outcome. We feel it is useful to highlight this case in an effort to stimulate interest and further study into the oncological potential of MDB biological and receptor therapy....

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Case Reports 2008; 29(6): 867-870 PubMed PMID: 19112415 Citation  Keywords:  Adult, Brain Neoplasms:complications, Central Nervous System Neoplasms:complications, Humans, Lymphoma, B-Cell:complications, Magnetic Resonance Imaging, Male, Multiple Sclerosis, Relapsing-Remitting:complications,.   

: We present the patient with the diagnosis of multiple sclerosis (MS), relapsing-remitting form with long lasting remission. Unexpectedly, this patient presented dramatical clinical deterioration and revealed clinical symptoms such as bradypsychia, cognitive symptoms, central vestibulare syndrome, spastic quadruparesis. Clinical findings suggested secondary progressive MS, but MRI called in question this diagnosis. The MRI appearance suggested, that MS had been complicated by a different brain pathological lesion, and the brain biopsy was indicated. A histological examination confirmed primary CNS lymphoma (PCNSL). This case exemplifies important aspects of clinical neurology. A re-evaluation of the diagnosis of MS should always be performed in a patient when new symptoms are presented that are unusual or could be due to other pathological processes. MRI offers the highly sensitive way to detect the coexistence of MS and other brain disease. Primary goal of imaging modalities is differential diagnosis between demyelinating diseases, such as MS and other brain lesions. Advanced focus demand contrast- enhancing and mass- effect lesions. It is important to realize, that contrast-enhancement and brain edema may be mitigated by treatment with corticosteroids. In some cases a brain biopsy is needed....

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