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Developmental programming of the hypothalamus: a matter of insulin. A comment on: Horvath, T. L., Bruning, J. C.: Developmental programming of the hypothalamus: a matter of fat. Nat. Med. (2006) 12: 52-53.

Plagemann A, Davidowa H, Harder T, Dudenhausen J.
Letter 2006; 27(1-2): 70-72 PubMed PMID: 16648802 Citation  Keywords:  Animals, Diabetes Mellitus:physiopathology, Hypothalamus:physiology, Insulin:physiology, Mice, Mice, Obese, Neuropeptide Y:physiology, Pro-Opiomelanocortin:physiology,.   

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Insulin-induced changes of proteolytic activity of the lysosomal enzymes.

Witek B, Ochwanowska E, Kolataj A, Król T, Baranowska D, Rafay J.
Comparative Study 2004; 25(1-2): 83-86 PubMed PMID: 15159689 Citation  Keywords:  Animals, Antigens, CD13:metabolism, Blood Glucose:analysis, Cathepsin D:metabolism, Cathepsin L, Cathepsins:metabolism, Cysteine Endopeptidases, Down-Regulation, Female, Insulin:physiology, Kidney:enzymology, Leucyl Aminopeptidase:metabolism, Liver:enzymo.   

OBJECTIVES: Changes in the activity of alanine aminopeptidase, leucine aminopeptidase and cathepsins D and L in the liver and kidney of male and female of mice, injected with 0.4 IU/kg b.w. insulin for 4 and 8 days.

METHODS: The homogenates of the liver and kidney were taken for examination. The activity of alanine aminopeptidase, leucine aminopeptidase and cathepsins D and L has been determined according to [1] method.

RESULTS: The activity of alanine aminopeptidase, leucine aminopeptidase, cathepsins D and L in the liver and kidney of male and female of mice decreased in effect of insulin injections for 4 and 8 days.

CONCLUSION: The changes of enzyme activities showed a stimulating effect of the insulin injection on the labilization of lysosomal membranes. The range of the reaction remained in a relationship with the kind of the organ, the type of enzyme, time over which insulin introduced operates in the organism, and with the sex....

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