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Clinical Trial 2004; 25(6): 438-442 PubMed PMID: 15665807 Citation  Keywords:  Adult, Estradiol:blood, Follicle Stimulating Hormone:blood, Humans, Hypothalamo-Hypophyseal System:drug effects, Klinefelter Syndrome:blood, Luteinizing Hormone:blood, Male, Naloxone:administration & dosage, Narcotic Antagonists:administration & dosage, P.   

UNLABELLED: AIM TO THE STUDY: The investigation of the influence of anti-opioid drug on hypophyseal and gonadal hormones secretion in case of Klinefelter syndrome.

MATERIAL AND METHODS: The naloxone test (0,4 mg iv) was performed in 14 patients with Klinefelter syndrome aged from 19 to 32 and in 12 age matched control subjects with azoospermia and normal spermatogenesis in testicular histology. The plasma levels of FSH, LH, prolactin, testosterone and estradiol were established before and after 30, 60, 60 and 120 minutes respectively, following the drug administration.

RESULTS: Basal FSH, prolactin and estradiol levels were significantly higher whereas basal testosterone was significantly lower in patients with Klinefelter syndrome than in the control group. After the naloxone administration the mean plasma prolactin level decreased significantly (p=0.01) in Klinefelter subjects. The respective diminution in control group was not significant. The levels of FSH and LH as well as testosterone and estradiol did not change during the naloxone test in both Klinefelter and control subjects.

CONCLUSIONS: The naloxone administration in Klinefelter syndrome caused the decrease in plasma prolactin levels but did not affect the plasma level of another hypophyseal and gonadal hormones. The opioid controlled gonadotropin secretion is altered in case of Klinefelter syndrome....

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Journal Article 2003; 24(5): 321-324 PubMed PMID: 14647004 Citation  Keywords:  Adult, Coitus, Humans, Klinefelter Syndrome:blood, Male, Sexual Dysfunction, Physiological:blood, Testosterone:blood, Varicocele:blood,.   

OBJECTIVES: The aim of our study is to assess the relationship between serum testosterone levels and the coital activity in groups of married men with Klinefelter's syndrome and in men with a varicocele investigated for marital infertility. These are compared with a group of somatosexually well developed men with a normozoospermia and adequate sexual life.

SUBJECT AND METHODS: The serum testosterone levels were assessed in 77 patients with Klinefelter's syndrome (mean age 31 years, SD 5.78), 58 men with a varicocele (mean age 30.5 years, SD 5.80) and 85 healthy men with normal spermiological values (mean age 32.7 years, SD 6.31). The frequency of sexual intercourse in their marriage was assessed by interview.

RESULTS: We found that, although their serum testosterone levels were significantly lower (p < 0.01), the coital activity in both groups with somatosexual disorders did not significantly differ from the group of men with normal semen parameters. The coital activity in the group of men with Klinefelter's syndrome decreased after 35 years of age, before any decrease in serum male sex hormone levels occurred.

CONCLUSION: Statistical analysis revealed that coital activity did not correlate with testosterone levels, but correlated significantly with age. A possible interpretation of the data is that Mother Nature ensues the survival of species by the production of not only a redundant amount of spermatozoids, but also of male sex hormones....

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