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Nosocomial meningitis caused by Enterobacteriaceae: risk factors and outcome in 18 cases in 1992-2007.

Benca J, Ondrusova A, Rudinsky B, Bauer F, Kovac M.
Journal Article 2007; 28(Suppl 2): 27-29 PubMed PMID: 17558373 Citation  Keywords:  Anti-Bacterial Agents:therapeutic use, Child, Child, Preschool, Cross Infection:drug therapy, Drug Resistance, Bacterial, Enterobacteriaceae Infections:complications, Female, Humans, Infant, Infant, Newborn, Male, Meningitis, Bacterial:drug therapy, Risk .   

: Nosocomial neuroinfections due to Enterobacteriaceae represented 9.5% in our cohort of 171 cases of paediatric meningitis within last 15 years. Commonest etiologic agents was E. coli - 9 (50%) followed by Klebsiella pneumoniae - 3 (16,7%) and Enterobacter cloacae. Citrobacter freundii, Proteus mirabilis and Salmonella enteritidis (1 each). Commonest risk factors were neonatal age 13 - (72.2%), very low birth weight 5 (27.8%), craniocerebral trauma - 4 (22.2%) and neurosurgery - 5 (27.8%). All but 1 case were treated with antibiotics: 8 with III-rd and 3 with IV-th generation cephalosporins (ceftazidim, cefotaxim and cefepim) 2 with meropenem and 4 with ciprofloxacin: Nosocomial meningitis due to enterobacteriaceae was associated with significantly high mortality (29.9% vs. 15.1% in all cohort of pediatric meningitis - p<0.02)....

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Fungal neuroinfections: rare disease but unacceptably high mortality.

Njambi S, Huttova M, Kovac M, Freybergh P, Bauer F, Muli J.
Journal Article 2007; 28(Suppl 2): 25-26 PubMed PMID: 17558372 Citation  Keywords:  Acquired Immunodeficiency Syndrome:complications, Antifungal Agents:therapeutic use, Brain Abscess:complications, Candidiasis:drug therapy, Child, Child, Preschool, Humans, Infant, Infant, Newborn, Meningitis, Cryptococcal:complications, Meningitis, Funga.   

: Within last 25 years we have observed 20 cases of fungal meningitis and/or cerebral abscesses. Commonest etiologic agens was Candida spp. (C. albicans 9 of 20). Molds were responsible for 4 cases of brain abscess. Mortality was 50% what seems to be very high. Extremely high mortality is caused by delayed onset of therapy, severe underlying disease and multiresistant fungal organisms such as Mucorales, Fusarium solani and Aureobasidium....

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Central nervous system complications of endocarditis.

Kovac M.
Journal Article 2007; 28(Suppl 2): 22-24 PubMed PMID: 17558371 Citation  Keywords:  Aneurysm, Infected:etiology, Anti-Infective Agents:therapeutic use, Bacterial Infections:complications, Brain:microbiology, Central Nervous System Diseases:etiology, Cerebrovascular Disorders:etiology, Endocarditis:complications, Humans, Meningitis:etiolo.   

: Neurologic complications of infective endocarditis, risk factors for mortality and neurologic sequellae are briefly reviewed....

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Insufficient therapy for nosocomial meningitis negatively affects survival, sequellae and has social consequences.

Huttova M, Beno P, Benca J, Ondrusova A, Kisac P, Rudinsky B, Kovac M, Bauer F, Sramka M.
Letter 2007; 28(Suppl 2): 20-21 PubMed PMID: 17558369 Citation  Keywords:  Aminoglycosides:therapeutic use, Anti-Bacterial Agents:therapeutic use, Carbapenems:therapeutic use, Child, Child, Preschool, Cross Infection:drug therapy, Drug Therapy, Combination, Humans, Infant, Infant, Newborn, Meningitis, Bacterial:drug therapy, Ret.   

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National 14 years survey of 171 cases nosocomial meningitis in children and comparison of two periods 1993-1998 to 1999-2006.

Rudinsky B, Ondrusova A, Kisac P, Sramka M, Beno P, Miklosko J, Freybergh P, Bauer F, Huttova M.
Comparative Study 2007; 28(Suppl 2): 11-14 PubMed PMID: 17558366 Citation  Keywords:  Child, Child, Preschool, Cross Infection:epidemiology, Data Collection, Gram-Negative Bacterial Infections:epidemiology, Humans, Infant, Infant, Newborn, Meningitis, Bacterial:epidemiology, Risk Factors, Slovakia:epidemiology, Staphylococcal Infections:ep.   

: In 1993-1998 and in 1999-2004 we have performed two surveys of pediatric bacterial meningitis in all 8 neurosurgery/pediatrics and infectious diseases departments in Slovakia. We have detected 101 and another 54 cases with attributable mortality of 15% and sequellae in 18%....

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Etiology, risks factors, therapy of nosocomial cerebrovascular infections.

Ondrusova A, Mutuku J, Rudinsky B, Sabo I, Kovac M.
Journal Article 2007; 28(Suppl 2): 7-10 PubMed PMID: 17558365 Citation  Keywords:  Anti-Infective Agents:therapeutic use, Cerebrovascular Disorders:etiology, Cross Infection:etiology, Humans, Meningitis:etiology, Postoperative Complications:etiology, Risk Factors,.   

: Nosocomial cerebrovacsular infections are substantial cause of mortality and morbidity in patients after neurosurgery. Risk factors, etiology, treatment strategies and outcome of nosocomial meningitis and brain abscess are briefly reviewed....

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