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Journal Article 2008; 29(4): 581-588 PubMed PMID: 18766137 Citation  Keywords:  Adiponectin:blood, Adipose Tissue:chemistry, Angioplasty, Balloon, Coronary, Humans, Leptin:blood, Male, Middle Aged, Myocardial Infarction:blood, Predictive Value of Tests, Prognosis, Resistin:blood,.   

OBJECTIVES: The objective of the study was to assess the impact of adipokines on the future major adverse cardiac events (MACE) in patients with acute myocardial infarction.

METHODS: Subjects were 77 men with first, ST-segment elevation acute myocardial infarction undergoing primary percutaneous coronary intervention in whom data were available after one year follow-up. Baseline clinical and angiographic data were collected, blood level of C-reactive protein, uric acid, fasting glucose, lipid profile, adiponectin, resistin and leptin and left ventricular ejection fraction on echocardiography were assessed. MACE was defined as cardiac death, nonfatal myocardial infarction, hospitalization for angina or heart failure.

RESULTS: 12% of patients experienced MACE. As revealed by univariate logistic regression analysis predictors of MACE were diabetes, multivessel disease, ejection fraction, blood C-reactive protein and adiponectin level. In multivariable analysis diabetes (OR=22.19, 95%CI 1.22-402.19; p=0.0360), lower left ventricular ejection fraction (OR=0.78, 95%CI 0.63-0.98; p=0.0298) and lower adiponectin level (OR=0.19, 95%CI 0.04-0.90; p=0.0362) were independent negative predictors of MACE. The optimal value of adiponectin for predicting MACE was 4.23 microg/ml. CONCLUSION. In male patients with myocardial infarction undergoing primary percutaneous coronary intervention, a baseline blood adiponectin but not resistin or leptin is independently predictive of MACE. The other prognostic factors are diabetes mellitus and left ventricular ejection fraction....

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Comparative Study 2007; 28(4): 427-432 PubMed PMID: 17693973 Citation  Keywords:  Adipokines:blood, Adipose Tissue:metabolism, Angioplasty, Balloon, Coronary, Blood Glucose:metabolism, C-Reactive Protein:metabolism, Cholesterol, HDL:blood, Humans, Male, Middle Aged, Myocardial Infarction:blood, Obesity:blood, Regression Analysis, Risk .   

UNLABELLED: Adipose tissue appears to be a key regulator of CRP levels. C-reactive protein (CRP), a marker of systemic inflammation, predicts the occurrence of diabetes, the metabolic syndrome and atherosclerotic diseases. Adipokines, the proteins produced by adipocytes are additional factors thought to be involved in the chronic, subclinical inflammatory state of adiposity.

AIM: The aim of the study was to assess the impact of obesity on the blood CRP levels and the relation of CRP to coronary risk factors and adipokines in men with acute myocardial infarction (AMI).

METHODS: The study was performed in 37 obese (BMI> or =30) and 33 lean patients (BMI<25) with first AMI treated with percutaneous coronary intervention within the initial 6 hours of AMI. Clinical data, anthropometric measurements, biochemical parameters and blood adipokines concentration were analyzed.

RESULTS: Values of the following parameters were significantly higher in obese than in lean patients: CRP, fasting glucose, glucose at admission, leptin and resistin, whereas HDL-cholesterol and adiponectin levels were lower. In univariate regression analysis CRP was related to obesity, HDL-cholesterol, fasting glucose, glucose at admission and adipokines but only glucose at admission and resistin were the independent positive factors and adiponectin an independent negative factor associated with CRP levels (R2= 51.1%).

CONCLUSIONS: In the early stage of AMI inflammation is more pronounced in obese than in lean patients. The pleiotropic association between CRP and obesity, adipokines and cardiovascular risk factors might prove it to be an important link between inflammatory reaction and atherogenesis in which adipose tissue hormones are involved....

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Comparative Study 2007; 28(2): 182-186 PubMed PMID: 17435665 Citation  Keywords:  Adult, Aged, Gonadal Steroid Hormones:blood, Humans, Lipoproteins:blood, Male, Middle Aged, Myocardial Infarction:blood,.   

OBJECTIVE: To compare the serum levels of total testosterone(TT), free testosterone (FT), estradiol, sex hormone binding globulin (SHBG), and androstenedione (AS) in patients with acute myocardial infarction (AMI) at the time of hospitalization, patients with old myocardial infarction (OMI), and patients with normal coronary arteries (NC) admitted for diagnostic coronary angiography.

METHODS: Serum sex hormones and lipid profile were measured in 79 male patients; 30 patients with AMI, 21 patient with OMI and 28 patients with NC. Ages ranged from 33-68 years. Androstenedione, estrogen, both total and free testosterone levels were quantified using coat-a-count radioimmunoassay kits. Sex hormone binding globulin was analyzed using immunoradiometric assay (IRMA)-count kits.

RESULTS: The levels of serum estradiol in the AMI were significantly higher and serum levels of TT, FT, and SHBG were significantly lower in AMI than in OMI and NC but there was no difference found for the levels of AS in all groups. Estradiol level was also higher in OMI than in control group but no significant changes found for other sex hormones in OMI and control group. Also triglyceride, high density and low density lipoprotein in AMI were significantly different from that in OMI and control groups.

CONCLUSIONS: Serum estradiol and low density lipoprotein levels are increased but TT, FT and SHBG levels are decreased in men with AMI compared with patients with NC....

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Journal Article 2003; 24(5): 355-380 PubMed PMID: 14647013 Citation  Keywords:  Circadian Rhythm, Epilepsy:physiopathology, Humans, Models, Biological, Myocardial Infarction:physiopathology,.   

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Comparative Study 2002; 23(5-6): 391-395 PubMed PMID: 12500159 Citation  Keywords:  Animals, Coloring Agents, Cytoprotection:drug effects, DNA:analysis, Disease Models, Animal, Drug Evaluation, Preclinical, Drug Therapy, Combination, Growth Hormone:therapeutic use, Heart:drug effects, Male, Melatonin:therapeutic use, Myocardial Infarctio.   

OBJECTIVE: To examine the cytoprotective effect of melatonin or recombinant human growth hormone (hGH) on the early phase of a running myocardial infarction in rats by using the Feulgen staining.

METHODS: Rats were subjected to surgical ligature of the left coronary artery or its sham-operation and were studied 1.5 3 h later. Melatonin was administered in the drinking water (100 microg/ml water) for 7 days before surgery. Recombinant hGH (2 IU/kg) was given ip at the time of surgery. Feulgen-stained histological cardiac sections were examined by light microscopy and image analysis.

RESULTS: Infarcted rats receiving vehicle exhibited large, diffuse cardiac lesions with a marked positivity for Feulgen reaction. About 18 20% of the total area recorded became injured 1.5 or 3 h after infarction, respectively. Infarcted rats treated with melatonin or hGH, or the combination of both, and killed 3 h after surgery, showed cardiac sections with scattered lesions and only a few isolated injured muscle fibers. A similar effectiveness of melatonin and hGH, alone or in combination, to decrease injured area by 86 87% and the number of cardiac lesions by 75 80% was observed.

CONCLUSION: A significant cytoprotective effect of melatonin or hGH is demonstrable in an early phase of myocardial infarction in rats....

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