Search NEL Online

Journal Article 2012; 33(4): 361-371 PubMed PMID: 22936259 Citation  Keywords:  Clone Cells:pathology, Humans, Neoplasms:etiology, Thermodynamics,.   

: The essence of life is best manifested in cell, which, when brought to the edge of its existence in the actual environment may and sometimes must self-organise into an entirely different cell (neoplasm), but it must enhance dissipation of matter and energy in its closest environment. This phenomenon has been described before as self-organisation of dissipative structures in physics, chemistry and even sociology. Each neoplastic cell is such a dissipative system - with its clonal growth, the cell causes increasing disorganisation of the body, in consequence leading to neoplastic disease. The only adequate cause of formation of neoplasms is an internal dissipathogenic cellular state, which is clinically identify as preneoplastic ones at the level of morphology or molecular biology but also biophysics. Two general directions for therapy of neoplastic diseases arise from the thermodynamic essence of neogenesis: the direct one - targeting neoplasms, and the indirect one - leading to normalisation or sufficient alteration of their environment. The greatest disappointment in the fight against neoplasm was the discovery of its thermodynamic cause in a natural self-organisation of biological dissipative structures. It is this dissipation that causes the signs and symptoms of neoplastic diseases ending with destruction of the body if the treatment comes too late and/or is insufficient, limited only to removal of neoplastic lesions without the always necessary elimination and/or prevention of preneoplastic (dissipathogenic) states....

Read abstract  Full text PDF

Journal Article 2009; 30(5): 671-674 PubMed PMID: 20035265 Citation  Keywords:  Aged, Aged, 80 and over, Animals, Chlamydia Infections:complications, Chlamydia trachomatis:immunology, Female, Humans, Middle Aged, Vulvar Lichen Sclerosus:etiology, Vulvar Neoplasms:etiology,.   

OBJECTIVE: Chronic infections in the urogenital area often precede or coexist with vulvar cancer. A strong connection between some tumours and the-appearance of Chlamydia trachomatis infection has been observed, but there is little information concerning a connection of that infection with vulvar cancer and lichen sclerosus vulvae (LS). The aim of this study was the analysis of frequency of antigens appearance and antibodies of IgM and IgG Chlamydia trachomatis in patients with vulvar cancer and LS and we wanted to find the correlation between Chlamydia trachomatis infection and vulvar cancer and LS.

METHODS: 80 women treated in the Clinic of Vulva Diseases at the Department and Clinical Ward of Gynaecology, Obstetrics and Oncological Gynaecology in Bytom, in the Silesian Medical University in Katowice were divided into two groups - 30 were treated for vulvar cancer and 50 were treated because of LS. We took bacterial smears vagina and cervical smears for presence of Chlamydia trachomatis antigens and peripheral blood to mark antibodies of IgM and IgG Chlamydia trachomastis.

RESULTS: Chlamydia trachomatis antigen was found in 20% women with vulvar cancer and in 12% women with LS (p>0.05). In 13,3% cases with vulvar cancer we observed IgM Chlamydia trachomatis antibodies. In the group with LS IgM antibodies appeared in 16% women (p>0.05). In 50% patients with vulvar cancer in blood serum we observed IgG Chlamydia trachomatis antibodies, and in 16% women with LS (p<0.001).

CONCLUSIONS: Previous Chlamydia trachomatis infection can lead to vulvar carcinogenesis....

Read abstract  Full text PDF

Journal Article 2008; 29(6): 815-821 PubMed PMID: 19112419 Citation  Keywords:  Animals, Chronobiology Disorders:complications, Circadian Rhythm, Humans, Melatonin:physiology, Neoplasms:etiology,.   

: For two decades, research has been suggested and conducted into the causation and development of cancers in seemingly diverse and unrelated populations such as blind individuals, shift-workers, flight personnel, Arctic residents and subsets of sleepers. One common denominator of these investigations is "melatonin". Another common denominator is that all these studies implicitly pursued the validity of the so-called "melatonin hypothesis", of a corollary and of associated predictions which can be united in our proposed theory of "carcinogenesis due to chronodisruption". The new theory suggests that the various predictions investigated between 1987 and 2008 represent different aspects of the same problem. Indeed, abundant experimental evidence supports the notion that the final common cause of many cases of cancer may be what has been termed chronodisruption (CD), a relevant disturbance of the temporal organization or order of physiology, endocrinology, metabolism and behaviour. While melatonin as a key time messenger and time keeper can be a marker of CD, it is probably only partially related to the differential cancer occurrence apparent in individuals who chronically or frequently experience an excess or deficit of chronodisruption....

Read abstract  Full text PDF

Clinical Trial 2008; 29(1): 107-112 PubMed PMID: 18283256 Citation  Keywords:  Acromegaly:complications, Adenoma:etiology, Adult, Aged, Blood Glucose:metabolism, Colonic Polyps:etiology, Colorectal Neoplasms:etiology, Female, Growth Hormone:blood, Homeostasis:physiology, Humans, Hyperinsulinism:complications, Insulin:blood, Insulin .   

INTRODUCTION: Pathogenesis of colonic lesions in patients with acromegaly remains still unclear. There are suggestions that apart from somatotropin axis hormones (GH and IGF-1), other agents also take part in this process. Molecular and animal studies indicate a vital role of hyperinsulinemia in development of colorectal neoplasms.

AIM OF THE STUDY: To evaluate a relation between insulin level, insulin resistance and its anthropometric markers and colorectal lesions in patients with acromegaly.

MATERIAL AND METHODS: The study consisted of 40 patients with active, newly diagnosed acromegaly; 24 women and 16 men aged from 24 to 77 years (mean age 50.1, SD+/-12.1). The analysis included the results of somatotropin axis function (GH and IGF-1 level), carbohydrate metabolism assessment (fasting serum glucose and insulin levels, oral glucose tolerance test, HOMA-IR for insulin resistance), the results of anthropometric measurement (BMI, WHR) and colonoscopy.

RESULTS: Colon pathologies (60 polyps and 2 flat lesions) were discovered in 19 (47.5%) patients with acromegaly, 8 of them had multiple polyps. Hyperplastic polyps were revealed in 11 (27.5%), while adenomas in 8 (20%) acromegalics. Patients with colorectal lesions were found to have higher WHR then subjects with normal colon (p=0.033). Positive correlation between the number of hyperplastic polyps in the patients with multiple changes in the colon and IGF-1 (p=0.025), insulin level (p=0.005) and HOMA-IR (p=0.001) was found. Multiple adenomas correlated positively with insulin level (p=0.007), HOMA-IR (p=0.006) and BMI (p=0.015).

CONCLUSIONS: The study results show a relation between hyperinsulinemia, insulin resistance and colon pathologies in acromegaly. Fasting insulin level and HOMA-IR correlate positively with the number of hyperplastic polyps and adenomas in acromegalic patients with multiply colorectal lesions....

Read abstract  Full text PDF

Comparative Study 2006; 27(Suppl 2): 86-90 PubMed PMID: 17159787 Citation  Keywords:  Adult, Bystander Effect:radiation effects, Carcinoma:etiology, Computer Simulation, Humans, Lung:radiation effects, Lung Neoplasms:etiology, Models, Biological, Neoplasms, Radiation-Induced, Radon Daughters:toxicity, Risk Factors, Smoking:adverse effects,.   

OBJECTIVES: Exposure to radon and radon decay products represents one of the greatest risks of ionizing radiation from natural sources in some residential and working areas. Recently increasing attention has been paid to accurate estimations of this health risk by using various models.

METHODS: In the presented study, a bystander model was used to predict biological effects of radon products on lung tissue target cells. The model considers radiation response as a superposition of the direct alpha particles hit effect and the bystander (cells communication) effect. Energy deposition in the lung tissue and in the air gap was calculated using the Bethe-Bloch equation. The exponential distribution of radon progenies in the mucous layer of smokers and non-smokers was evaluated.

RESULTS: The excess relative risk value of lung cancer occurrence per unit exposure obtained in our study was ERR/WLM=0.0047 for smokers and ERR/WLM=0.0171 (taking into account the environment in radioactive ore mines) for non-smokers. Other published results give the average excess relative risk values per unit exposure in the dwellings for smokers ERR=0.050 per 100 Bq.m(-3) and for non-smokers ERR=0.198 per 100 B.qm(-3). Results presented in this study are in good agreement with the published epidemiological data on lung cancer incidence for mines and residential areas.

CONCLUSIONS: The bystander model is suitable for radon risk prediction in dwellings and at workplaces (residential and working areas)....

Read abstract

Congresses 2002; 23(Suppl 2): 4-104 PubMed PMID: 12163856 Citation  Keywords:  Animals, Endocrine System:physiology, Humans, Light:adverse effects, Neoplasms:etiology,.   

...

Read abstract

Journal Article 2002; 23(Suppl 2): 28-36 PubMed PMID: 12163845 Citation  Keywords:  Animals, Humans, Light:adverse effects, Melatonin:physiology, Neoplasms:etiology, Photoperiod, Pineal Gland:physiology,.   

: The role of the modulation of the pineal gland function in development of cancer is discussed in the review. An inhibition of the pineal function with pinealectomy or with the exposure to the constant light regimen stimulates mammary carcinogenesis, whereas the light deprivation inhibits the carcinogenesis. Epidemiological observations on increased risk of breast cancer in night shift workers, flight attendants, radio and telegraph operators and on decreased risk in blind women are in accordance with the results of experiments in rodents. Treatment with pineal indole hormone melatonin inhibits carcinogenesis in pinealectomized rats or animals kept at the standard light/dark regimen (LD) or at the constant illumination (LL) regimen....

Read abstract  Full text PDF

Journal Article 2002; 23(Suppl 2): 9-13 PubMed PMID: 12163841 Citation  Keywords:  Animals, DNA Damage, Humans, Light:adverse effects, Melatonin:metabolism, Neoplasms:etiology, Neurodegenerative Diseases:etiology,.   

: This brief review summarizes some of the biological effects of light exposure at an inappropriate time (during the normal dark period) and the potential negative physiological consequences of this light exposure. Two major systems are significantly influenced by light at night. Thus, the circadian system and melatonin synthesis are altered when light is extended into the normal dark period or when the dark period is interrupted by light. This summary reviews the potential sequelae of chronic inappropriate light exposure and the suppression of endogenous melatonin levels. Given that melatonin is a free radical scavenger and antioxidant, conditions that involve free radical damage may be aggravated by light suppression of melatonin levels. The conditions of particular interest for this review are excessive DNA damage (which potentially leads to cancer), cellular destruction in neurodegenerative diseases and aging itself. Further research should be conducted to more accurately define the potential negative impact of light at abnormal times on animal and human pathophysiology....

Read abstract  Full text PDF