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Journal Article 2001; 22(4): 295-304 PubMed PMID: 11524636 Citation  Keywords:  Affect, Ethics, Medical, Fetus, Humans, Infant, Newborn, Nervous System Physiological Phenomena, Object Attachment, Parent-Child Relations, Perinatology:methods, Terminology as Topic, Touch:physiology, Ultrasonography, Prenatal:adverse effects,.   

: This article gives a short introduction to the science of Haptonomy and more specially to the application of its specific phenomenality of psychotactile affective contact and interaction during prenatal and postnatal life and during childbirth. The neurophysiological implications and the influence of this approach on the pain threshold are briefly mentioned, as well as psychological influences on the postnatal development of the child. Finally, there is a critical commentary on the use of the ultra-sound scan....

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Journal Article 2001; 22(4): 251-254 PubMed PMID: 11524632 Citation  Keywords:  Aging:physiology, Animals, Circadian Rhythm, Endocrine System Diseases:drug therapy, Female, Macaca mulatta, Melatonin:blood, Nervous System Diseases:drug therapy, Oligopeptides:therapeutic use, Osmolar Concentration,.   

UNLABELLED: The OBJECTIVE of this research was to investigate the regulatory effect of Epitalon on the production of melatonin and cortisol in senescent monkeys.

MATERIAL AND METHODS: We investigated the character of melatonin and cortisol secretion by immunoferment assay in Epitalon-administered female Macaca mulatta in different age periods.

RESULTS: Epitalon was proven to significantly stimulate melatonin synthesis in senescent monkeys in the evening, thereby normalising the circadian rhythm of cortisol secretion....

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Journal Article 2001; 22(3): 187-191 PubMed PMID: 11449191 Citation  Keywords:  Animals, Cell Division, Ganglionectomy, Ileum:cytology, Intestine, Small:cytology, Jejunum:cytology, Male, Melatonin:biosynthesis, Mitosis, Pineal Gland:innervation, Rats, Rats, Sprague-Dawley, Superior Cervical Ganglion:physiology, Sympathetic Nervous Sy.   

OBJECTIVES: To observe the effect of changes in the pineal sympathetic innervation on the crypt cell proliferation rate in the rat small intestine, and compare these with the effect of pinealectomy to determine the role of the sympathetic innervation in the effect of pinealectomy.

METHODS: The effect of bilateral ablation of the superior cervical ganglion, and that of pinealectomy on the crypt cell proliferation rate in the rat small intestine was determined, using a stathmokinetic technique.

RESULTS: Pinealectomy was associated with a considerably increased crypt cell proliferation rate, whereas superior cervical ganglionectomy was associated with a slightly decreased rate.

CONCLUSIONS: It appears likely that changes in pineal melatonin production cannot be correlated directly with the effects of pinealectomy on the crypts, although melatonin production was not measured in this case. The role of loss of the non-adrenergic innervation of the pineal in the effect of pinealectomy needs to be examined. There is also other experimental evidence that melatonin-free extracts of the pineal, containing as yet unidentified substances, can influence mitotic activity in some tissues, so the possible role of these substances in the effects of pinealectomy should also be considered. Furthermore, the superior cervical ganglion itself has an extra-pineal role. Changes in pineal sympathetic innervation are not significant in the hyperproliferative effects of pinealectomy on the intestinal crypts....

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Journal Article 2018; 39(3): 172-178 PubMed PMID: 30431742 Citation  Keywords:  Adipose Tissue:metabolism, Anorexia Nervosa:metabolism, Appetite, Bulimia Nervosa:metabolism, Ghrelin:metabolism, Glucuronidase:metabolism, Gonads:metabolism, Human Growth Hormone:metabolism, Humans, Hypothalamo-Hypophyseal System:metabolism, Insulin-Like.   

: Endocrine dysfunctions in eating disorders (anorexia nervosa, bulimia nervosa) result from disturbed regulation of hypothalamo-pituitary-gonadal, hypothalamo-pituitary-adrenal, hypothalamo-pituitary-thyroid and hypothalamo-pituitary-GH-IGF1 axes as well as of altered peripheral endocrine metabolism. Some peptides of hypothalamic origin, as well as those secreted by the adipose tissue and gastrointestinal tract including pancreatic hormones, are involved in the control of appetite and satiety. These peptides play also an important role in the mechanism of hormonal secretion. Altered activity of these biologically active substances may lead to the disturbances in the regulation of energy and hormonal homeostasis....

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